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The main purpose of this study is to compare the effect of 10 mg and 15 mg methotrexate in the treatment of meningeal carcinomatosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The small dose of group | Experimental | The dose of methotrexate is 10 mg |
|
| The high dose of group | Active Comparator | The dose of methotrexate is 15 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| methotrexate | Drug | The quantity of methotrexate is different in the two groups. |
|
| Measure | Description | Time Frame |
|---|---|---|
| overall survival | one year |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of adverse reactions | In accordance with the standard of CTCAE, an assessment will be assessed every month | one year |
| KPS score | In accordance with the standard of KPS(Karnofsky Performance Status,KPS) score, an assessment will be assessed every month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hui Bu | Contact | 86-13831106903 | buhuimy1@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Hui | The Second Hospital of Hebei Medical University | Principal Investigator |
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| ID | Term |
|---|---|
| D055756 | Meningeal Carcinomatosis |
| ID | Term |
|---|---|
| D008577 | Meningeal Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D008727 | Methotrexate |
| ID | Term |
|---|---|
| D000630 | Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| one year |
| D009369 | Neoplasms |
| D009422 | Nervous System Diseases |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |