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| Name | Class |
|---|---|
| CHU de Reims | OTHER |
| University Hospital, Strasbourg, France | OTHER |
| Centre Hospitalier Universitaire Dijon | OTHER |
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Studies on the cognitive function have highlighted promising results concerning attention. In contrast, in the field of memory, the single cohort study that has been carried out, has not been randomised, with non comparable groups, the significant outcomes are therefore to be balanced.
In this study, patients with focal and structural temporal lobe epilepsy will be randomised in 2 groups : the COMETE group where patients will attend a specific rehabilitation programme of memory and the control group where patients will benefit from a standard treatment.
Epilepsy is a chronic neurological disease among the most frequent ones. It causes cognitive disorders in 20 to 50 percent of patients with structural epilepsy, that is to say in connexion with an identified or presumed cerebral lesion. Compared to seizures, these cognitive disorders are a major additional factor of professional, social or family disability. They are particularly prevalent (50%) in temporal lobe epilepsy and preferentially affect language memory and abilities. These disorders are well described, they are multifactorial but no (drug and/or non drug) therapy has been validated yet.
Recently, techniques of cognitive rehabilitation have shown benefits in some neurological diseases, like multiple sclerosis.
Concerning adulthood epilepsy, the few cognitive rehabilitation studies that have been conducted present huge methodological gaps limiting the scope of theirs results.
Studies on the cognitive function have highlighted promising results concerning attention. In contrast, in the field of memory, the single cohort study that has been carried out, has not been randomised, with non comparable groups, the significant outcomes are therefore to be balanced.
Thus, in this study, patients with focal and structural temporal lobe epilepsy will be randomised in 2 groups : the COMETE group where patients will attend a specific rehabilitation programme of memory and the control group where patients will benefit from a standard treatment.
Work's hypothesis would be that patients undergoing the rehabilitation programme would present improved learning abilities (with impact on their memory performances) compared to patients with standard treatment.
This hypothesis is based on underlying theories of cognitive rehabilitation. This method predicts that by reinforcing some cognitive abilities that transfer to others, the improved learning abilities will also result in improved abilities in immediate memory, work memory, but will have no effect on verbal inhibition abilities, which will constitute a specific marker/indicator ? for the intervention. Moreover, patient care may have an impact on their quality of life and mood which are predictive factors for a good social and professional integration: that's why these indexes/criteria have to be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COMETE | Experimental | patients will attend a specific rehabilitation programme of memory |
|
| CONTROL | No Intervention | the control group where patients will benefit from a standard treatment |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| COMETE | Other | Patients of COMETE group will attend 12 individual sessions of cognitive rehabilitation, which are not systematic in usual treatment, and will receive memory exercises via internet to continue cognitive exercizes at home. |
| Measure | Description | Time Frame |
|---|---|---|
| Buschke Reminding Test, learning index | this is a task of verbal memory : neuropsychologist read a list of 15 words, and patient must repeat a maximum of them | 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| digit span | this is a task of immediate memory : neuropsychologist read digit, and subject must recall them in the same order | 5 minutes |
| Visual memory task | this is a task of visual memory : subject must memorize a grid |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| helene brissart, Dr | Contact | 0033383851689 | h.brissart@chu-nancy.fr | |
| louis maillard, Pr | Contact | 0033383852377 | l.maillard@chu-nancy.fr |
| Name | Affiliation | Role |
|---|---|---|
| jean pierre VIGNAL, DR | Central Hospital, Nancy, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Neurologie, Hôpital Central, CHRU de Nancy | Recruiting | Nancy | Lorraine | 54 035 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21176930 | Background | Brissart H, Daniel F, Morele E, Leroy M, Debouverie M, Defer GL. [Cognitive rehabilitation in multiple sclerosis: a review of the literature]. Rev Neurol (Paris). 2011 Apr;167(4):280-90. doi: 10.1016/j.neurol.2010.07.039. Epub 2010 Dec 21. French. | |
| 22853712 | Result | Brissart H, Leroy M, Morele E, Baumann C, Spitz E, Debouverie M. Cognitive rehabilitation in multiple sclerosis. Neurocase. 2013;19(6):553-65. doi: 10.1080/13554794.2012.701644. Epub 2012 Aug 1. |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| 10 minutes |
| verbal fluencies | The performance measure is the total number of words that patient give in two minutes. there is two conditions : phonological condition : patient must recall words that start with the letter P; semantic condition : patient must recall words from animal category | 5 minutes |
| Attentional tasks (TEA Battery) | This is attentional task on computer | 10 minutes |
| Beck Depression Inventory | this is an inventory of depression | 10 minutes |