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Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.
Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. More effective treatments are needed to induce changes in cardiac fat content, body composition, and cardiac fat metabolic activity that result in a reduction in cardiovascular risk in overweight and obese population. Despite this need, little is known about which mode, frequency, and duration of exercise will allow for greater reductions in cardiac fat, improvements in body composition, restoration of a healthy cardiac fat metabolic activity, and improvement on cardiovascular risk markers. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Intervention | Experimental | Hight intensity resistance training group |
|
| Control | No Intervention | No-exercise control group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Intervention | Other | The intervention will consist of 3 weeks of whole body circuit training (resistance training) where participants in the intervention group will perform 7 different exercises. The circuit will consist of 10 repetitions per exercise of 7 exercises: leg press, bent-over row, bench press, squats, dumbbell jump squats with raises, dead-lifts and weighted abdominal crunches, with approximately 30 sec of rest in between each exercise (based on the estimated time needed to move from one position to the next). Each participant will move through the circuit 3 times, with 2 to 3 minutes of rest between each round. Intensity will be 6-7 of RPE at the first set, and 9-10 at the third set. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Cardiac fat volumes | Cardiac fat volumes will be assessed by means of Magnetic Resonance Imaging | 2 assessment points: at baseline and week 4 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Vascular function | Vascular function will be assessed by means of Arterial Tonometry | 2 assessment points: at baseline and week 4 |
| Changes in Cardiorespiratory Function | Cardiorespiratory Function will be assessed on a treadmill test with a 12-lead EKG. Protocol: Modified Bruce (A baseline stage will be added) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maria Fernandez del Valle, PhD | Texas Tech University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kinesiology and Sport Management | Lubbock | Texas | 79423 | United States |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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|
| 2 assessment points: at baseline and week 4 |
| Changes in Muscular Strength | Muscular Strength in upper and lower extremities will be assessed by 1 repetition maximum (1RM) test on Bench Press and Leg Press | 2 assessment points: at baseline and week 4 |
| Changes in Body Composition | Body Composition will be assessed using Dual-energy x-ray absorptiometry | 2 assessment points: at baseline and week 4 |
| Changes in Diet | Diet will be assessed using the ASA24h recall (http://epi.grants.cancer.gov/asa24/) | 5 assessment points: baseline, week 1, 2, 3, and 4 |
| Changes in Spontaneous Physical Activity | Spontaneous Physical Activity will be assessed using accelerometers Actical. | Baseline and week 4 |
| Changes in Oxidative stress markers | Blood will be collected and processed in order to assess oxidative stress markers | 5 assessment points: pre-post during session 1, pre-post during session 9, and pre week 4. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |