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This case-control study investigated B-vitamin and homocysteine in relation to the presence or the absence of type 2 diabetes and clinical signs of polyneuropathy.
Blood samples were collected and clinical investigations were performed at the same time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with type 2 diabetes | Patients (both men and women) with diagnosed type 2 Diabetes for at least 5 years. Blood collection and electrophysiological tests were performed. |
| |
| Controls free of diabetes | Controls (both men and women) are people of the same age who are free of Diabetes. Blood collection and electrophysiological tests were performed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood collection and electrophysiological tests | Device | Blood collected using a conventional method. Electrophysiology was tested after nerve Stimulation. Medical history and symptoms were collected after a standardized interview. |
| Measure | Description | Time Frame |
|---|---|---|
| Red blood cell cobalamin levels | Baseline | |
| Polyneuropathy grade estimated using a score including a combination of data from questionnaire and electrophysiology investigations | Polyneuropathy grade was accessed using a questionnaire and a clinical examination (electrophysiology) after nerve stimulation. A score includes the combination of questionnaire data and electrophysiology data. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma methylmalonic acid levels | Baseline | |
| Plasma choline levels | Baseline | |
| Plasma cobalamin levels |
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Inclusion Criteria:
Exclusion Criteria:
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Male and female subjects with or without diabetes.
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| Name | Affiliation | Role |
|---|---|---|
| Rima Obeid, Dr. | University Hospital of the Saarland, Department of Clinical Chemistry | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Saarland | Homburg | Saarland | 66424 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23168250 | Result | Obeid R, Jung J, Falk J, Herrmann W, Geisel J, Friesenhahn-Ochs B, Lammert F, Fassbender K, Kostopoulos P. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimie. 2013 May;95(5):1056-61. doi: 10.1016/j.biochi.2012.10.028. Epub 2012 Nov 17. | |
| 26864355 | Derived | Obeid R, Awwad HM, Rabagny Y, Graeber S, Herrmann W, Geisel J. Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism. Am J Clin Nutr. 2016 Mar;103(3):703-11. doi: 10.3945/ajcn.115.121269. Epub 2016 Feb 10. |
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| ID | Term |
|---|---|
| D048909 | Diabetes Complications |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
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Fasting blood samples (serum, whole blood and EDTA-plasma)
| Baseline |