Impact of Extremely Early Antiretroviral Therapy to Reduce VIral REservoir and Induce Functional CURE of HIV-1 Infection

Impact of Extremely Early Antiretroviral Therapy to Reduce VIral REservoir and Induce Functional CURE of HIV-1 Infection: A Pilot Comparative Study

Pilot study to evaluate the impact of extremely early ART in the dynamics of viral reservoir, immune activation and inflammation in patients with HIV-1 infection of less than 20 days (Fiebig stages I-II) compared to patients with infection of 20-100 days (Fiebig stages III-V), to induce HIV functional cure.

Inclusion Criteria:

• Men who have sex with men
• Male's between18 and 65 years old
• Less than 100 days of infection
• Patient stage Fiebig I to V
• Negative or Incomplete western blot with negative p31 band

Exclusion Criteria:

• P31 positive band in western blot
• Positive Delta32 CCR5 mutation, HLA-B5701 or HLA-B27 (´late' exclusion criteria)
• Active oncological disease
• Active hepatitis C virus infection