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Study Goals:
Prospective non interventional study in the Department of Life Sciences, Bar-Ilan University and IVF Unit at Meir Hospital.
The control group consisting of 50 semen samples from men with no sperm problems and 50 vaginal samples from their partners.
The study group consisting of 50 semen samples from men with male fertility problems and 50 vaginal samples from their partners.
The semen taken from the remains after fertilization of the IVF laboratory. (Liquid otherwise routinely thrown).
Vaginal samples taken from women undergoing IVF treatment under anesthesia after informed consent.
Enrollment also collect the following data: age, race, chronic illnesses, past surgeries and former fertility treatments. Data will be collected through anamnesis of the patient or the medical file after consent.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control- semen | Semen of fertile men |
| |
| Control- vaginal discharge | Vaginal discharge of partners of fertile men |
| |
| Case-semen | Semen of infertile men |
| |
| Case- vaginal discharge | Vaginal discharge of partners of infertile men |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| The percent of successful IFV treatments | Using 16-S Ribosomal RNA analysis to quantify and compare (type and percentages) of bacterial components in sperm samples from fertile and infertile men and their impact on IVF treatments success rate | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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Infertile coupls
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23775377 | Background | Trussell JC. Optimal diagnosis and medical treatment of male infertility. Semin Reprod Med. 2013 Jul;31(4):235-6. doi: 10.1055/s-0033-1345269. Epub 2013 Jun 17. No abstract available. | |
| 21117930 | Background | Rittenberg V, El-Toukhy T. Medical treatment of male infertility. Hum Fertil (Camb). 2010 Dec;13(4):208-16. doi: 10.3109/14647273.2010.534833. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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Semen and vaginal discharge
| 14535856 | Background | Diemer T, Huwe P, Ludwig M, Hauck EW, Weidner W. Urogenital infection and sperm motility. Andrologia. 2003 Oct;35(5):283-7. |
| 9350723 | Background | Goldenberger D, Kunzli A, Vogt P, Zbinden R, Altwegg M. Molecular diagnosis of bacterial endocarditis by broad-range PCR amplification and direct sequencing. J Clin Microbiol. 1997 Nov;35(11):2733-9. doi: 10.1128/jcm.35.11.2733-2739.1997. |
| 22316585 | Background | Akutsu T, Motani H, Watanabe K, Iwase H, Sakurada K. Detection of bacterial 16S ribosomal RNA genes for forensic identification of vaginal fluid. Leg Med (Tokyo). 2012 May;14(3):160-2. doi: 10.1016/j.legalmed.2012.01.005. Epub 2012 Feb 7. |
| 22341372 | Background | Domes T, Lo KC, Grober ED, Mullen JB, Mazzulli T, Jarvi K. The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters. Fertil Steril. 2012 May;97(5):1050-5. doi: 10.1016/j.fertnstert.2012.01.124. Epub 2012 Feb 16. |
| Background | Bacteriospermia and sperm quality in infertile male patient |
| 21091298 | Background | De Francesco MA, Negrini R, Ravizzola G, Galli P, Manca N. Bacterial species present in the lower male genital tract: a five-year retrospective study. Eur J Contracept Reprod Health Care. 2011 Feb;16(1):47-53. doi: 10.3109/13625187.2010.533219. Epub 2010 Nov 23. |
| 23993888 | Background | Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, Abdo Z, Forney LJ, Xu C. Microbiota of the seminal fluid from healthy and infertile men. Fertil Steril. 2013 Nov;100(5):1261-9. doi: 10.1016/j.fertnstert.2013.07.1991. Epub 2013 Aug 29. |
| 25340531 | Background | Weng SL, Chiu CM, Lin FM, Huang WC, Liang C, Yang T, Yang TL, Liu CY, Wu WY, Chang YA, Chang TH, Huang HD. Bacterial communities in semen from men of infertile couples: metagenomic sequencing reveals relationships of seminal microbiota to semen quality. PLoS One. 2014 Oct 23;9(10):e110152. doi: 10.1371/journal.pone.0110152. eCollection 2014. |