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General anesthesia, even in patients in good health, impairs gas exchanges and ventilatory mechanics. These effects result primarily from atelectasis formation. They occur in 85-90% of healthy patients in the minutes following the induction when a positive end expiratory pressure (PEEP) is not used.
The functional residual capacity (FRC) of obese patients during general anesthesia is even smaller than the one of healthy patients. There is a direct relationship between the body mass index and the decrease of the functional residual capacity. Obese patients have therefore more atelectasis. The increased abdominal pressure during the pneumoperitoneum will increase the decrease of the CRF, and thus aggravate the formation of these atelectasis.
Atelectasis affect the peroperative gas exchanges and are likely to be involved in the worsening of postoperative hypoxemia episodes. In addition, atelectasis alter the clearance of secretions and the lymph flow, which predispose to lung infections.Taking all these factors into account, it is logical to think that the atelectasis presence can lead to an increase of the postsurgical morbidity (respiratory distress, infections). That is why actively fighting against the formation of these atelectasis is important.
There is a lack of scientific evidence to say that the strategies against atelectasis as PEEP have a significant impact on the patient's postoperative status. The expected clinical benefits balance (reduction of respiratory distress episodes, infections and mortality) versus the risks linked to the maneuvers done to reduce the development of atelectasis (barotraumas, cardiac complications) remains to be determined.
The primary goal of this study is to evaluate the impact of two different alveolar recruitment strategies on the incidence of postoperative hypoxemia in obese patients after bariatric surgery.
The secondary objectives of this study are to compare the number of recruitment maneuvers, the Pa02 / FI02 ratio (ratio of arterial oxygen partial pressure to fractional inspired oxygen), the dynamic compliance, the anatomic dead space and intraoperative PaCO2-EtCO2 gradient (arterial and end tidal gradient) between two alveolar recruitment strategies applied in obese patients during laparoscopic bariatric surgery (gastric bypass or sleeve gastrectomy).
The tertiary objectives of this study are to report the number of respiratory complications and postoperative wound infections at the 30th postoperative day.
General anesthesia, even in patients in good health, impairs gas exchanges and ventilatory mechanics. These effects result primarily from atelectasis formation. They occur in 85-90% of healthy patients in the minutes following the induction when a positive end expiratory pressure (PEEP) is not used.
These atelectasis are formed on one hand by the reduction of the functional residual capacity (FRC) following a compression mechanism (loss of the inspiratory muscle tone, which is accompanied by a chest wall configuration change and a diaphragm cephalic movement) and on the other hand by a denitrogenation absorption process (ventilation at high Fi02 (oxygen inspired fraction) causing complete absorption of O2 with lack of support for the alveolus, which then collapses).
The FRC of obese patients during general anesthesia is even smaller than the one of healthy patients. There is a direct relationship between the body mass index and the decrease of the functional residual capacity. Obese patients have therefore more atelectasis. The increased abdominal pressure during the pneumoperitoneum will increase the decrease of the CRF, and thus aggravate the formation of these atelectasis.
Atelectasis affect the peroperative gas exchanges and are likely to be involved in the worsening of postoperative hypoxemia episodes. In addition, atelectasis alter the clearance of secretions and the lymph flow, which predispose to lung infections.Taking all these factors into account, it is logical to think that the atelectasis presence can lead to an increase of the postsurgical morbidity (respiratory distress, infections). That is why actively fighting against the formation of these atelectasis is important.
Several strategies have been studied in order to improve respiratory mechanics and reduce impaired gas exchange during laparoscopic surgery in obese patients. The position called "chair", mechanical ventilation with PEEP, recruitment maneuvers followed by the PEEP, and spontaneous ventilation with CPAP before extubation, are all strategies that have proven effective to decrease development these atelectasis.
Currently, the scientific community agrees on the fact that PEEP improves intraoperative respiratory function (improved compliance, oxygenation) especially in conjunction with recruitment maneuvers.
But there is a lack of scientific evidence to say that the strategies against atelectasis as PEEP have a significant impact on the patient's postoperative status. The expected clinical benefits balance (reduction of respiratory distress episodes, infections and mortality) versus the risks linked to the maneuvers done to reduce the development of atelectasis (barotraumas, cardiac complications) remains to be determined.
The primary goal of this study is to evaluate the impact of two different alveolar recruitment strategies on the incidence of postoperative hypoxemia in obese patients after bariatric surgery.
The secondary objectives of this study are to compare the number of recruitment maneuvers, the Pa02 / FI02 ratio, the dynamic compliance, the anatomic dead space and intraoperative PaCO2-EtCO2 gradient between two alveolar recruitment strategies applied in obese patients during laparoscopic bariatric surgery (gastric bypass or sleeve gastrectomy).
The tertiary objectives of this study are to report the number of respiratory complications and postoperative wound infections at the 30th postoperative day.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PEEP 10 cmH20 | Experimental | In this group, a PEEP of 10 cmH20 is applied for the duration of the intervention and a recruitment maneuver is applied each time the SpO2 (oxygen pulsated saturation) drops below 95%. |
|
| optimal PEEP | Active Comparator | In this group, 10 cmH20 PEEP is applied immediately. Then the "optimal PEEP" is sought at three key moments. It is determined by the best value of lung compliance found in the patient. It is sought by increasing or decreasing the value of the PEEP by increments or decrements of 2 cmH20. If after 6 respiratory cycles, the value of the compliance is increased, the investigator continues to increase the value of the PEEP. On the other hand, if the value of compliance is reduced, the investigator reduces the value of PEEP. The value of the PEEP selected shall in no event exceed the set pressure range (maximum pressure plate of 30 cmH20 and maximum inspiratory peak pressure 40cmH20). A recruitment maneuver is applied each time the SpO2 drops below 95%, as in the PEEP 10cmH2O group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEEP (positive end-expiratory pressure) | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of hypoxemia episodes (Sp02<90%) | This will be monitored by a portable saturometer (OxyTrue A, Bluepoint, Germany). This saturometer will allow the investigators to count the number of hypoxemia episodes (Sp02<90%) and their duration in obese patients, in the postoperative period. | continuously during 48h after surgery |
| Number of hypoxemia episodes (Sp02<95%) | This will be monitored by a portable saturometer (OxyTrue A, Bluepoint, Germany). This saturometer will allow the investigators to count the number of hypoxemia episodes (Sp02<95%) and their duration in obese patients, in the postoperative period. | continuously during 48h after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Number of recruitment manoeuvers | Recruitment manoeuver are performed if patient saturation drops below 95%. | From the beginning of the surgery till moment 1 (after induction/intubation, patient laying flat, without pneumoperitoneum) |
| Number of recruitment manoeuvers |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippe Van der Linden, MD | CHU Brugmann | Principal Investigator |
| Van Hecke Delphine, MD | CHU Brugmann | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Brugmann | Brussels | 1020 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15105237 | Background | Coussa M, Proietti S, Schnyder P, Frascarolo P, Suter M, Spahn DR, Magnusson L. Prevention of atelectasis formation during the induction of general anesthesia in morbidly obese patients. Anesth Analg. 2004 May;98(5):1491-5, table of contents. doi: 10.1213/01.ane.0000111743.61132.99. | |
| 20824871 | Background | Imberger G, McIlroy D, Pace NL, Wetterslev J, Brok J, Moller AM. Positive end-expiratory pressure (PEEP) during anaesthesia for the prevention of mortality and postoperative pulmonary complications. Cochrane Database Syst Rev. 2010 Sep 8;(9):CD007922. doi: 10.1002/14651858.CD007922.pub2. |
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Recruitment manoeuver are performed if patient saturation drops below 95%. |
| From moment 1 till moment 2 (after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation) |
| Number of recruitment manoeuvers | Recruitment manoeuver are performed if patient saturation drops below 95%. | From moment 2 till moment 3 (after pneumoperitoneum exsufflation - patient lying flat) |
| Number of recruitment manoeuvers | Recruitment manoeuver are performed if patient saturation drops below 95%. | From moment 3 till the end of the surgery (patient leaving the theater) |
| Pulmonary dynamic compliance (Cd) - preoperative | This will be determined by the following formula: Cd = Vt/P(peak)-PEEP and expressed in mL/cmH2O | Just before surgery, at ambient air contact |
| Pulmonary dynamic compliance (Cd) - moment 1 | This will be determined by the following formula: Cd = Vt/P(peak)-PEEP and expressed in mL/cmH2O | just after the anesthesia induction/intubation, patient laying flat, without pneumoperitory |
| Pulmonary dynamic compliance (Cd) -moment 2 | This will be determined by the following formula: Cd = Vt/P(peak)-PEEP and expressed in mL/cmH2O | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Pulmonary dynamic compliance (Cd) -moment 3 | This will be determined by the following formula: Cd = Vt/P(peak)-PEEP and expressed in mL/cmH2O | just after pneumoperitoneum exsufflation - patient lying flat |
| Pulmonary dynamic compliance (Cd) -if recruitment manoeuvers | This will be determined by the following formula: Cd = Vt/P(peak)-PEEP and expressed in mL/cmH2O | Five minutes after any recruitment manoeuver |
| Anatomic dead space - preoperative | This will be determined by this formula: VD = VT (1-PEtCO2/PaC02) | Just before surgery, at ambient air contact |
| Anatomic dead space -moment 1 | This will be determined by this formula: VD = VT (1-PEtCO2/PaC02) | just after the anesthesia induction/intubation, patient laying flat, without pneumoperitory |
| Anatomic dead space -moment 2 | This will be determined by this formula: VD = VT (1-PEtCO2/PaC02) | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Anatomic dead space -moment 3 | This will be determined by this formula: VD = VT (1-PEtCO2/PaC02) | just after pneumoperitoneum exsufflation - patient lying flat |
| Anatomic dead space -if recruitment manoeuvers | This will be determined by this formula: VD = VT (1-PEtCO2/PaC02) | Five minutes after any recruitment manoeuver |
| PaO2/FiO2 ratio - preoperative | Arterial oxygen partial pressure to fractional inspired oxygen ratio | Just before surgery, at ambient air contact |
| PaO2/FiO2 ratio - moment 1 | Arterial oxygen partial pressure to fractional inspired oxygen ratio | just after the anesthesia induction/intubation, patient laying flat, without pneumoperitory |
| PaO2/FiO2 ratio - moment 2 | Arterial oxygen partial pressure to fractional inspired oxygen ratio | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| PaO2/FiO2 ratio - moment 3 | Arterial oxygen partial pressure to fractional inspired oxygen ratio | just after pneumoperitoneum exsufflation - patient lying flat |
| PaO2/FiO2 ratio - if recruitment manoeuvers | Arterial oxygen partial pressure to fractional inspired oxygen ratio | Five minutes after any recruitment manoeuver |
| PaCO2-EtCO2 gradient - preoperative | The gradient between the partial pressure of carbon dioxide in the arterial blood (PaCO2) and the CO2 end-tidal partial pressure (EtCO2) is used to evaluate the effectiveness of alveolar recruitment. | Just before surgery, at ambient air contact |
| PaCO2-EtCO2 gradient - moment 1 | The gradient between the partial pressure of carbon dioxide in the arterial blood (PaCO2) and the CO2 end-tidal partial pressure (EtCO2) is used to evaluate the effectiveness of alveolar recruitment. | just after the anesthesia induction/intubation, patient laying flat, without pneumoperitory |
| PaCO2-EtCO2 gradient - moment 2 | The gradient between the partial pressure of carbon dioxide in the arterial blood (PaCO2) and the CO2 end-tidal partial pressure (EtCO2) is used to evaluate the effectiveness of alveolar recruitment. | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| PaCO2-EtCO2 gradient - moment 3 | The gradient between the partial pressure of carbon dioxide in the arterial blood (PaCO2) and the CO2 end-tidal partial pressure (EtCO2) is used to evaluate the effectiveness of alveolar recruitment. | just after pneumoperitoneum exsufflation - patient lying flat |
| PaCO2-EtCO2 gradient - if recruitment manoeuvers | The gradient between the partial pressure of carbon dioxide in the arterial blood (PaCO2) and the CO2 end-tidal partial pressure (EtCO2) is used to evaluate the effectiveness of alveolar recruitment. | Five minutes after any recruitment manoeuver |
| Number of respiratory complications | Number of hospitalisations due to respiratory complications within 30 days after surgery. | 30 days after surgery |
| Number of postoperative wound infections | All patients are seen at the surgical consultation on day 30 after surgery. The anamnesis performed during that consultation enables the investigators to identify patients with wound infections (defined as a need for local or oral antibiotics, additional hospitalisation or abnormal cicatrisation). | 30 days after surgery |
| Pre-operative physiologic measures: cardiac frequency (FC) | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | Just before surgery, at ambient air contact |
| Pre-operative physiologic measures: Arterial tension (TA) | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | Just before surgery, at ambient air contact |
| Pre-operative physiologic measures: pH | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | Just before surgery, at ambient air contact |
| Pre-operative physiologic measures: partial pressure of carbon dioxide in the arterial blood (PaCO2) | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens). | Just before surgery, at ambient air contact |
| Operative physiologic measures - moment 1: FC | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after induction/intubation, patient laying flat, without pneumoperitoneum |
| Operative physiologic measures - moment 1: PAM (Average arterial pressure) | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after induction/intubation, patient laying flat, without pneumoperitoneum |
| Operative physiologic measures - moment 1: pH | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after induction/intubation, patient laying flat, without pneumoperitoneum |
| Operative physiologic measures - moment 1: PaCO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after induction/intubation, patient laying flat, without pneumoperitoneum |
| Operative physiologic measures - moment 1: CO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after induction/intubation, patient laying flat, without pneumoperitoneum |
| Operative physiologic measures - moment 2: FC | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Operative physiologic measures - moment 2: PAM | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Operative physiologic measures - moment 2: pH | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Operative physiologic measures - moment 2: PaCO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Operative physiologic measures - moment 2: CO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Operative physiologic measures - moment 3: FC | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after pneumoperitoneum exsufflation - patient lying flat |
| Operative physiologic measures - moment 3: PAM | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after pneumoperitoneum exsufflation - patient lying flat |
| Operative physiologic measures - moment 3: pH | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | just after pneumoperitoneum exsufflation - patient lying flat |
| Operative physiologic measures - moment 3: CO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after pneumoperitoneum exsufflation - patient lying flat |
| Operative physiologic measures - moment 3: PaCO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after pneumoperitoneum exsufflation - patient lying flat |
| Operative physiologic measures - if recruitment manoeuvers occurs: FC | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | Five minutes after any recruitment manoeuver |
| Operative physiologic measures - if recruitment manoeuvers occurs: PAM | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | Five minutes after any recruitment manoeuver |
| Operative physiologic measures - if recruitment manoeuvers occurs: SpO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | Five minutes after any recruitment manoeuver |
| Operative physiologic measures - if recruitment manoeuvers occurs: pH | The hemodynamic and respiratory parameters of the patient are measured by means of a Datex-Ohmeda Acertys machine (Aisys type). | Five minutes after any recruitment manoeuver |
| Operative physiologic measures - if recruitment manoeuvers occurs: PaCO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | Five minutes after any recruitment manoeuver |
| Operative physiologic measures - if recruitment manoeuvers occurs: PaO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | Five minutes after any recruitment manoeuver |
| Operative physiologic measures - if recruitment manoeuvers occurs: CO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | Five minutes after any recruitment manoeuver |
| Pre-operative physiologic measures: partial pressure of oxygen in the arterial blood (PaO2) | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | Just before surgery, at ambient air contact |
| Operative physiologic measures - moment 1: PaO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after induction/intubation, patient laying flat, without pneumoperitoneum |
| Operative physiologic measures - moment 2: PaO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Operative physiologic measures - moment 3: PaO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after pneumoperitoneum exsufflation - patient lying flat |
| Pre-operative physiologic measures: Oxygen Pulsated Saturation (SpO2) | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | Just before surgery, at ambient air contact |
| Operative physiologic measures - moment 1: SpO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after induction/intubation, patient laying flat, without pneumoperitoneum |
| Operative physiologic measures - moment 2: SpO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after peritoneal insufflation and anti-trendenlenbourg (anti-trent) implementation |
| Operative physiologic measures - moment 3: SpO2 | The gasometric parameters of the patient are analyzed with a Rapidlab 1265 machine (Siemens) | just after pneumoperitoneum exsufflation - patient lying flat |
| 12456460 | Background | Eichenberger A, Proietti S, Wicky S, Frascarolo P, Suter M, Spahn DR, Magnusson L. Morbid obesity and postoperative pulmonary atelectasis: an underestimated problem. Anesth Analg. 2002 Dec;95(6):1788-92, table of contents. doi: 10.1097/00000539-200212000-00060. |
| 16368847 | Background | Whalen FX, Gajic O, Thompson GB, Kendrick ML, Que FL, Williams BA, Joyner MJ, Hubmayr RD, Warner DO, Sprung J. The effects of the alveolar recruitment maneuver and positive end-expiratory pressure on arterial oxygenation during laparoscopic bariatric surgery. Anesth Analg. 2006 Jan;102(1):298-305. doi: 10.1213/01.ane.0000183655.57275.7a. |
| 21068660 | Background | Futier E, Constantin JM, Pelosi P, Chanques G, Kwiatkoskwi F, Jaber S, Bazin JE. Intraoperative recruitment maneuver reverses detrimental pneumoperitoneum-induced respiratory effects in healthy weight and obese patients undergoing laparoscopy. Anesthesiology. 2010 Dec;113(6):1310-9. doi: 10.1097/ALN.0b013e3181fc640a. |
| 19403595 | Background | Almarakbi WA, Fawzi HM, Alhashemi JA. Effects of four intraoperative ventilatory strategies on respiratory compliance and gas exchange during laparoscopic gastric banding in obese patients. Br J Anaesth. 2009 Jun;102(6):862-8. doi: 10.1093/bja/aep084. Epub 2009 Apr 29. |
| 19809292 | Background | Reinius H, Jonsson L, Gustafsson S, Sundbom M, Duvernoy O, Pelosi P, Hedenstierna G, Freden F. Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study. Anesthesiology. 2009 Nov;111(5):979-87. doi: 10.1097/ALN.0b013e3181b87edb. |
| 10551570 | Background | Pelosi P, Ravagnan I, Giurati G, Panigada M, Bottino N, Tredici S, Eccher G, Gattinoni L. Positive end-expiratory pressure improves respiratory function in obese but not in normal subjects during anesthesia and paralysis. Anesthesiology. 1999 Nov;91(5):1221-31. doi: 10.1097/00000542-199911000-00011. |
| 15310643 | Background | Tusman G, Bohm SH, Suarez-Sipmann F, Turchetto E. Alveolar recruitment improves ventilatory efficiency of the lungs during anesthesia. Can J Anaesth. 2004 Aug-Sep;51(7):723-7. doi: 10.1007/BF03018433. |
| 18165575 | Background | Maisch S, Reissmann H, Fuellekrug B, Weismann D, Rutkowski T, Tusman G, Bohm SH. Compliance and dead space fraction indicate an optimal level of positive end-expiratory pressure after recruitment in anesthetized patients. Anesth Analg. 2008 Jan;106(1):175-81, table of contents. doi: 10.1213/01.ane.0000287684.74505.49. |
| 19443420 | Background | Strang CM, Hachenberg T, Freden F, Hedenstierna G. Development of atelectasis and arterial to end-tidal PCO2-difference in a porcine model of pneumoperitoneum. Br J Anaesth. 2009 Aug;103(2):298-303. doi: 10.1093/bja/aep102. Epub 2009 May 13. |
| 15673897 | Background | Gander S, Frascarolo P, Suter M, Spahn DR, Magnusson L. Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients. Anesth Analg. 2005 Feb;100(2):580-584. doi: 10.1213/01.ANE.0000143339.40385.1B. |
| 19122544 | Background | Hans GA, Sottiaux TM, Lamy ML, Joris JL. Ventilatory management during routine general anaesthesia. Eur J Anaesthesiol. 2009 Jan;26(1):1-8. doi: 10.1097/EJA.0b000e000000f1fb. |
| 18270353 | Background | Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008 Feb 13;299(6):646-55. doi: 10.1001/jama.299.6.646. |
| 19996966 | Background | Gattinoni L, Carlesso E, Brazzi L, Caironi P. Positive end-expiratory pressure. Curr Opin Crit Care. 2010 Feb;16(1):39-44. doi: 10.1097/MCC.0b013e3283354723. |
| 30612327 | Derived | Van Hecke D, Bidgoli JS, Van der Linden P. Does Lung Compliance Optimization Through PEEP Manipulations Reduce the Incidence of Postoperative Hypoxemia in Laparoscopic Bariatric Surgery? A Randomized Trial. Obes Surg. 2019 Apr;29(4):1268-1275. doi: 10.1007/s11695-018-03662-x. |
| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
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| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
Not provided
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