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determine if efficiency of MEOPA anesthesia is at least equivalent to local anesthetics into the chorionic villus sampling in the first trimester of pregnancy
Compare anxiety discomfort and side effects
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxygen/nitrous oxide equimolar mix | Active Comparator | 96 participants undergoing chorionic villi sampling. self administered inhalation of equimolar mixture of oxygen and nitrous oxide (MEOPA) |
|
| Lidocaine | Active Comparator | 96 participants undergoing chorionic villi sampling infiltrative local anaesthesia of 1% lidocaine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxygen/nitrous oxide equimolar mix | Drug | an experimental strategy inhalation by means of a breathing mask diffusing MEOPA |
|
| Measure | Description | Time Frame |
|---|---|---|
| Analgesia efficiency | assessment of pain with visual analog scale | 5 min after procedure |
| Measure | Description | Time Frame |
|---|---|---|
| assessment of anxiety | assessment of anxiety with visual analog scale | 5 min after biopsy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Raoul Desbriere, MD | Hôpital st Joseph Marseille France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital St Joseph | Marseille | 13008 | France |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D010100 | Oxygen |
| C576493 | Meopa |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D018011 | Chalcogens |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D005740 | Gases |
| D000083 |
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| Lidocaine | Drug | standard strategy by local injection anesthesia of lidocaine |
|
| Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |