This is an open-label, randomized, multi-center, single dose, two-period, two-sequence crossover study to investigate the bioequivalence of PEG-IFN alfa-2a BA-free formulation versus the reference market formulation (PEG-IFN alfa-2a [Pegasys®]) following subcutaneous administration via prefilled syringe in healthy Chinese participants.

Inclusion Criteria:

• Healthy female and male Chinese participants
• Body mass index between 19 and 28 kilograms per square meter (kg/m^2), inclusive
• Participants determined as healthy by their medical history, physical examination, vital signs, electrocardiogram (ECG), and clinical laboratory measurements performed at the Screening visit
• Female participants of childbearing potential: willing to use highly effective methods of contraception throughout the study and for 90 days after the last dosing
• Male participants: agreement to remain abstinent or use spermicide and barrier method contraception throughout the study and for 90 days after the last dosing
• Able to participate and willing to give written informed consent and to comply with the study restrictions

Exclusion Criteria:

• Any clinically relevant condition or history of cardiovascular, psychiatric, gastrointestinal, respiratory, renal, hepatic, hematological, lymphatic, neurological (including seizure history), musculoskeletal, genitourinary, immunological, metabolic, malignant, or dermatological disorder
• Participants who are positive for hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (anti HCV) or human immunodeficiency virus I and II antibody (anti-HIV I, anti-HIV II) tests at Screening
• Participants with alanine aminotransferase (ALT) above the upper limit of normal at Screening or on Day -1 of Period 1
• Any other condition or disease (other than those already stated) which, in the judgment of the Investigator, would place the participant at undue risk, interfere with the absorption, distribution, metabolism, and excretion of PEG-IFN alfa-2a, or interfere with the ability of the participant to complete the study
• History of drug or alcohol abuse within the last year before screening
• Treatment with interferon or PEG-IFN alfa-2a within 3 months prior to the first dosing
• Female participants who are pregnant, currently lactating, or have a positive serum pregnancy test at screening or have a positive urine pregnancy test on Day -1 of Period 1
• Use of any prescribed or over the counter medication or herbal medicine taken within 14 days prior to the first dosing or within 5 times the elimination half-life of the medication prior to the first dosing (whichever is longer). Exceptions are paracetamol, the contraceptive pill, hormone replacement therapy and commonly used vitamin supplements, which are permitted
• Regular smoking with consumption of more than 10 cigarettes per day or an equivalent amount of tobacco
• Participation in an investigational drug or device study within 3 months prior to the first dosing