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| Name | Class |
|---|---|
| Massachusetts General Hospital | OTHER |
| Harvard Medical School (HMS and HSDM) | OTHER |
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Blocking of reconsolidation by pharmacological or behavioral means offers the therapeutic possibility of weakening traumatic memories in posttraumatic stress disorder (PTSD). Two reconsolidation-based interventions, propranolol and extinction learning, have been shown to weaken fear memories in human healthy subjects. However, the success of these interventions seems to be limited to weak conditioned fear memories. This calls for new, potentially more efficacious, interventions to be tested. Bilateral eye movements seem to be a promising candidate intervention for blocking reconsolidation due to the compelling evidence of Eye Movement Desensitization and Reprocessing as effective treatment in PTSD. The investigators' aim is to test bilateral eye movements as an active reconsolidation-blocking intervention in an optimized differential fear conditioning procedure that the investigators have recently developed. This novel experimental assay creates stronger fear memories in healthy individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Delayed Bilateral Eye Movements | Experimental | Delayed Bilateral Eye Movements after reactivation of fear-memory. |
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| Undelayed Bilateral Eye Movements | Active Comparator | Undelayed Bilateral Eye Movements after reactivation of fear-memory. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Delayed Bilateral Eye Movements | Behavioral | Bilateral Eye Movements followed by a 10 min delay after reactivation of fear-memory. |
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| Measure | Description | Time Frame |
|---|---|---|
| Skin conductance (SC) response | Change from Day 1 (acquisition) fear conditioned SC response at day 3 (testing of renewal, reinstatement) and day 30 follow-up (testing of spontaneous recovery/renewal, savings) |
| Measure | Description | Time Frame |
|---|---|---|
| Blood oxygenation level dependent (BOLD) response | Change from Day 1 (acquisition) fear conditioned BOLD response at day 3 (testing of renewal, reinstatement) and day 30 follow-up (testing of spontaneous recovery/renewal, savings) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Mueller-Pfeiffer, MD | University Hospital of Zurich, Department of Psychiatry and Psychotherapy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich, Department of Psychiatry and Psychotherapy | Zurich | Canton of Zurich | 8091 | Switzerland |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| Undelayed Bilateral Eye Movement | Behavioral | Bilateral Eye Movements followed by no delay after reactivation of fear-memory. reactivation of the fear memory trace during which the reactivated memory is assumed to be in a labile state. |
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