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| Name | Class |
|---|---|
| Klinik Hirslanden, Zurich | OTHER |
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Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.
A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention in this retrospective study | Other | No Intervention in this retrospective Analysis. All patients included did receive Radiation therapy Independent of this study |
| Measure | Description | Time Frame |
|---|---|---|
| Calculation of the organ-specific excess lifetime attributable risk (LAR) (%) | LAR is calculated for variable Ages at exposure | 60 years (model-based calculation) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients having had radiation therapy for rectal cancer. Estimation of second cancer risk using data from planning CTs comparing dose Distribution using different Radiation therapy techniques (3DCRT vs VMAT).
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| Name | Affiliation | Role |
|---|---|---|
| Daniel R Zwahlen, MD, MBA | Kantonsspital Graubuenden | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik Hirslanden, Institute for Radiotherapy | Zurich | CH-8032 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27832799 | Derived | Zwahlen DR, Bischoff LI, Gruber G, Sumila M, Schneider U. Estimation of second cancer risk after radiotherapy for rectal cancer: comparison of 3D conformal radiotherapy and volumetric modulated arc therapy using different high dose fractionation schemes. Radiat Oncol. 2016 Nov 10;11(1):149. doi: 10.1186/s13014-016-0723-6. |
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| ID | Term |
|---|---|
| D016609 | Neoplasms, Second Primary |
| ID | Term |
|---|---|
| D009369 | Neoplasms |
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