Ginger Capsules for the Acute Treatment of Migraine Attacks

Double-blind Placebo-controlled Clinical Trial of Ginger (Zingiber Officinale) Addition to Ketoprofen for the Acute Treatment of Migraine Attacks

The main objective of the study was to evaluate ginger efficacy as an adjuvant to ketoprofen for the treatment of headache and other symptoms related with migraine attacks.

Patients with the diagnosis of migraine according to the International Headache Society (IHS) criteria were enrolled in the study during a migraine attack. Patients received two 200 mg capsules of dry ginger extract (5% active ingredient) or two capsules of placebo (cellulose) in addition to an intravenous dose of ketoprofen (100 milligrams - mg) to treat the migraine attack.

• Inclusion Criteria:

  • Migraine diagnosis for at least one year;
  • Migraine attack with moderate or severe pain intensity;
  • One to six migraine attacks per month.

• Exclusion Criteria:

  • Patients with headaches not characterized as migraine;
  • Pregnant or lactating women;
  • Fertile and sexually active women who do not use contraception;
  • Abuse of painkillers, alcohol or drugs;
  • People with hypersensitivity to ginger;
  • People with other neurological diseases;
  • People in use of anticoagulant drugs;
  • People who have started the disease after 50 years old.