Hypofractionated Stereotactic Radiotherapy for Patients With Recurrent High Grade Glioma

Phase II Study of Hypofractionated Stereotactic Radiotherapy for Patients With Recurrent High Grade Glioma

The study is aimed to evaluate efficacy and safety of re-irradiation for patients with recurrent high grade gliomas after other treatment.

Investigators designed this study of a re-irradiation with single radiosurgery or hypofractionated intensity modulated radiation therapy (IMRT) with or without temozolomide.

Objective of the study is evaluating efficacy and safety of re-irradiation for patients with recurrent high grade gliomas after other treatment.

Inclusion Criteria:

• Age > 18 years
• Karnosky performance status (KPS) ≥70
• Patients aged >70 years with KPS ≥80
• Histopathologically confirmed grade III-IV glioma
• Estimated survival ≥ 3 months
• Any Tumor volume
• Unifocal tumor
• Interval time from previous radiotherapy ≥ 6mesi
• Normal liver, Kidney and bone marrow function
• Written informed consent

Exclusion Criteria:

• KPS < 70
• Multifocal tumor
• Other primary cancer
• Pregnant women