The purpose of this study is to evaluate the safety and efficacy of Restylane Lidocaine and Restylane Perlane Lidocaine after the first and second treatment when used for facial augmentation in Asian population.

Inclusion Criteria:

• Subjects intent to undergo facial filler treatment for either volume loss or contouring
• Subjects requiring treatment in two to four of pre-defined areas in the face (upper cheeks, nasolabial folds, temples, nose and chin)
• Require 3-5 ml of investigational products to achieve a clinically meaningful improvement in appearance
• Facial appearance as Han Chinese
• Non-pregnant, non-breast feeding female
• Signed informed consent

Exclusion Criteria:

• Previous facial surgery (e.g. rhinoplasty) or permanent implant in the area to be treated.
• History of chronic sinusitis or rhinitis (only applicable for subjects injected in the nose).
• Subjects who needs to use heavy glasses during the study (only applicable for subjects injected in the nose).
• Previous tissue augmenting therapy or contouring with permanent filler or fat injection in the facial area.
• Previous treatment with Hyaluronic acid (HA) fillers or Restylane Skinboosters in the facial area within 12 months before treatment.
• Previous treatment with non-HA fillers such as CaHA (Calcium Hydroxylapatite) or PLLA (Poly L-Lactic Acid) within 24 months before treatment.
• Previous revitalization with neurotoxin in the facial area within six (6) months before treatment.
• Previous tissue revitalization treatment with laser or light, mesotherapy, chemical peeling or dermabrasion in the facial area within six (6) months before treatment.
• Any medical condition that, in the opinion of the investigator, would make the subject unsuitable for inclusion (e.g. a chronic, relapsing or hereditary disease that may interfere with the outcome of the study).

2 years, 4 months

Each subject was to be questioned about AEs at each study visit following the Screening Visit.

The question to be asked was:"Since your last clinical visit have you had any health problems?" Information on AEs could also be obtained from signs and symptoms detected during an examination or from a laboratory test, observations made by the study site personnel, subject diaries, or spontaneous reports from subjects or their relatives.