A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism

A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism

Studies of myocardial fuel selection using a novel palmitate-based PET probe

A novel Positron Emission Tomography (PET) probe, 16- 18-F-fluoro-4-thiapalmitate, will be used to evaluate myocardial atty acid uptake. Studies will be done in humans with type 2 diabetes mellitus, and in controls. Studies will take place on 2 separate days, under fasting conditions and under insulin clamp conditions.

Inclusion Criteria:

• Lean:

  • BMI<25 kg/m2
  • normal glucose tolerance by 75g oral glucose tolerance test

• Type 2 diabetes mellitus:

  • BMI >25 kg/m2
  • previously diagnosed type 2 diabetes mellitus
  • on oral and/or injected insulin treatment.

Exclusion Criteria:

• Lean:

  *Use of any chronic medications

• Type 2 diabetes mellitus

  • known microvascular disease
  • known coronary or other macro vascular disease
  • use of PPARgamma class antidiabetic agents within 6 months