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In preschool aged children, the most suitable techniques to assess airway obstruction is debit interruption technic (Rint) and plethysmographic measure of specific airway resistance (sRaw). Even if Rint is easily and routinely performed, it also includes a component of lung tissue and chest wall resistance as well as respiratory tissue viscoelasticity. sRaw seems to be better for discriminating airway obstruction. These two techniques will be compared in terms of concordance in the diagnosis of pulmonary obstruction and bronchodilator response.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| airway resistance measurement | Experimental | interruption and plethysmography techniques airway resistance measurement at each routine visit |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| airway resistance measurement | Other | assessment of airway resistance |
|
| Measure | Description | Time Frame |
|---|---|---|
| airway resistance measure by interruption technique (Rint) | Rint is performed using Spiroteq Dyn'R during a 100 ms occlusion and calculated using the linear back extrapolation method | Day one |
| Measure | Description | Time Frame |
|---|---|---|
| measure of bronchodilator response | Bronchodilator response is assessed with Rint and sRaw measurement | Day one |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marie-Agnès METGES, Pr | University Hospital of Brest | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Brest | Brest | 29609 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31945475 | Derived | Mauger-Hamel P, Du Boisbaudry C, Leon K, Alavi Z, Giroux-Metges MA. Relationship between baseline and post-bronchodilator interrupter resistance and specific airway resistance in preschool children. Ann Allergy Asthma Immunol. 2020 Apr;124(4):366-372. doi: 10.1016/j.anai.2020.01.003. Epub 2020 Jan 13. |
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| ID | Term |
|---|---|
| D000402 | Airway Obstruction |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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