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This is a single center non-interventional study in healthy participants for behavioral assessment and fMRI assessments. The study will consist of 2 parts. Part A will involve 5 participants and will study the implementation of the behavioral tests and identify potential issues. Part B will involve 30 participants and will study the test-retest reliability. Duration of participation for each participant will be 30 days for Part A (28 days screening period and 2 days of study visit) and 48 days for Part B (28 days screening period and 2 study visits of 2 days each separated by a period of 14 days).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All Participants | Healthy participants will undergo behavioral assessment and fMRI. |
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| Measure | Description | Time Frame |
|---|---|---|
| Intra Class Coefficient of Correlation (ICC) of the Task Activated Blood Oxygenation Level-Dependent (BOLD) fMRI: Face Matching Task | Day 1 | |
| ICC of the Task Activated BOLD fMRI: Monetary Incentive Delay Task | Day 1 | |
| ICC of the Task Activated BOLD fMRI: 2 vs 0 Back Working Memory Task | Day 1 | |
| ICC of the Task Activated BOLD fMRI: Episodic memory Task (Encoding, Recall, and Recognition of Face-Profession Pairs) | Day 1 | |
| ICC of the Task Activated BOLD fMRI: Theory of Mind Task (ToM; To Make Inferences About Others Mental States Using 32 False-Belief Cartoon Stories) | Day 1 | |
| ICC of the Resting-State BOLD fMRI, Acquired Using Gradient Echo-Planar Imaging (EPI) Images | Screening (Day -28 to Day -1) | |
| ICC of the Resting-State Arterial Spin Labeling (ASL) to Measure Cerebral Blood Flow, Acquired Using Gradient EPI Images | Screening (Day -28 to Day -1) | |
| ICC of the out of Scanner Behavioral Tasks: Stop Signal Reaction Time (SSRT) to Assess the Time Required to Stop Already Executed Response | Day 1 | |
| ICC of the out of Scanner Behavioral Tasks: California Verbal Learning Test - Second Edition (CVLT-II), to Assess an Individual's Episodic Verbal Learning and Memory Abilities |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy Participants
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| PRA Health Sciences Early Development Services | Zuidlaren | 9471 GP | Netherlands |
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Whole blood for DNA extraction
| Day 2 |
| Out of Scanner Behavioral Tasks: RAVEN General Intelligence Test | Screening (Day -28 to Day -1) |
| ICC of the out of Scanner Behavioral Tasks: Emotional Test Battery (ETB), Assessed Using Facial Expression Recognition Task (FERT) and Faces Dot Probe Task (FDOT) to Measure Biases in Emotional Processing | Day 1 |
| ICC of the out of Scanner Behavioral Tasks: Reward Learning Tasks (Reinforcement Learning and Working Memory Task) | Day 2 |
| ICC of the Task Activated BOLD fMRI: Go/No-Go Task | Day 1 |