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| ID | Type | Description | Link |
|---|---|---|---|
| 91713354 | Other Grant/Funding Number | Dutch Scientific Foundation (ZonMw) | |
| EA1027 | Other Grant/Funding Number | The European Foundation for Alcohol Research (ERAB) |
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This current project investigates the effect of a single session of right dlPFC repetitive transcranial magnetic stimulation on emotion regulation abilities and craving in alcohol dependent patients and healthy controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Repetitive Transcranial Magnetic Stimulation (rTMS) | Experimental | Repetitive Transcranial Magnetic Stimulation: Active 10hz stimulation over the right dorsolateral Prefrontal Cortex (dlPFC) |
|
| Sham stimulation | Sham Comparator | Repetitive Transcranial Magnetic Stimulation: sham stimulation over the right dlPFC |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Repetitive Transcranial Magnetic Stimulation | Device | Repetitive 10Hz right DLPFC stimulation using Magstim TMS apparatus |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in BOLD response during an emotion regulation task (fMRI) | BOLD response was measured during an emotion regulation task. The change in BOLD response between sessions is the primary outcome for this study | Change in BOLD response from baseline, compared to BOLD response after stimulation (approximately two weeks later) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in experienced emotion during an emotion regulation task with Visual Analogue Scales (VAS) | Participants were instructed to either 'attend' or 'regulate' their emotion associated with the presented (negatively valenced) pictures. Experienced (or regulated) emotion was assessed with visual analogue scales (VAS). | Change in experienced emotion from baseline, and after the stimulation session (approximately two weeks later) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anneke E Goudriaan, Prof dr. | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25477246 | Background | Jansen JM, van Holst RJ, van den Brink W, Veltman DJ, Caan MW, Goudriaan AE. Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls. Addict Biol. 2015 Sep;20(5):979-89. doi: 10.1111/adb.12199. Epub 2014 Dec 5. | |
| 23916527 | Result |
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| ID | Term |
|---|---|
| D000437 | Alcoholism |
| D000080103 | Emotional Regulation |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| Change in craving levels [Alcohol Urge Questionnaire (AUQ)] | The AUQ was administered in order to assess craving levels. The AUQ consists of eight statements wich are rated on a 7 point likert scale [0 = Strongly disagree, 6 = Strongly Agree] | Before and after the emotion regulation task, during both baseline and stimulation session (e.g. 4 time points, sessions were separated by approximately two weeks) |
| Jansen JM, Daams JG, Koeter MW, Veltman DJ, van den Brink W, Goudriaan AE. Effects of non-invasive neurostimulation on craving: a meta-analysis. Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2472-80. doi: 10.1016/j.neubiorev.2013.07.009. Epub 2013 Jul 31. |
| 31133889 | Derived | Jansen JM, van den Heuvel OA, van der Werf YD, de Wit SJ, Veltman DJ, van den Brink W, Goudriaan AE. The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing, Reappraisal, and Craving in Alcohol Use Disorder Patients and Healthy Controls: A Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2019 May 7;10:272. doi: 10.3389/fpsyt.2019.00272. eCollection 2019. |
| 31057439 | Derived | Jansen JM, van den Heuvel OA, van der Werf YD, de Wit SJ, Veltman DJ, van den Brink W, Goudriaan AE. Emotion Processing, Reappraisal, and Craving in Alcohol Dependence: A Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2019 Apr 9;10:227. doi: 10.3389/fpsyt.2019.00227. eCollection 2019. |
| D000068356 | Self-Control |
| D012919 | Social Behavior |
| D001519 | Behavior |