Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes

Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes: the DiabOS Study

This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.

Cross-sectional evaluation of clinical, biochemical and microstructural measures of bone in patients with type 2 diabetes and age-matched healthy controls. Longitudinal assessment of clinical, biochemical and microstructural measures of bone in study participants without prevalent fragility fractures.

Inclusion Criteria:

- presence of type 2 diabetes for at least 3 years (history of treatment for type 2 diabetes)

Exclusion Criteria:

• immobility
• coexisting metabolic bone disease or comorbidities affecting bone health
• previous treatment with osteoporosis medication or intake of medications known to affect bone metabolism (e.g. steroids) within 6 months prior to enrolment
• thiazolidinedione use