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The study aims to asses the ability of cell tests based on the analysis of the anti-Aspergillus cell responses and identify Aspergillus bronchitis with patients with cystic fibrosis.
In addition, the study will evaluate the contribution of biological classification of aspergillosis according to criteria recently proposed by Baxter et al. compared to the classification used in clinical practice in the hospital of Montpellier.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cystic fibrosis | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| T specific response for diagnostic of aspergillus bronchitis | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of CD4 T cell response against Aspergillus fumigatus in patients with cystis fibrosis | Analysis T cells response for identification of aspergillus bronchitis with cystic fibrosis patients | 12 months |
| Cytokine level of TCD8 | Qualitative Evaluation of cytokine level (IFNg, TNFa, IL10 and IL4) of TCD8 to identify ABPA and aspergillus bronchitis | 12 months |
| Cytokine level CD4 cells | Qualitative Evaluation of cytokine level CD4 cells in order to identify ABPA and aspergillus bronchitis | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Level of fumigatus specific IgE | Contribution of several biological tests improve classification of aspergillus bronchitis | 12 months |
| Level of fumigatus specific IgG | Contribution of several biological tests improve classification of aspergillus bronchitis |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Irmb/U1058 | Montpellier | 34000 | France |
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| 12 months |
| Real-time PCR for aspergillus in sputum | Contribution of several biological tests improve classification of aspergillus bronchitis | 12 months |
| Galactomannan by enzyme immune assay detection in sputum | Contribution of several biological tests improve classification of aspergillus bronchitis | 12 months |
| Levels of cytokine (IFNg, IL10, IL4 and TNF) evaluated by flow cytometry | Contribution of several biological tests improve classification of aspergillus bronchitis | 12 months |
| Level of IL10 evaluated by Elispot dedicated to anti-aspergillus CD4 T cells | Contribution of several biological tests improve classification of aspergillus bronchitis | 12 months |
| Flow cytometry techniques dedicated to anti-aspergillus CD4 T cell assessment | 12 months |
| Level of IFNg evaluated by Elispot dedicated to anti-aspergillus CD4 T cells | Contribution of several biological tests improve classification of aspergillus bronchitis | 12 months |
| Elispot dedicated to anti-aspergillus CD4 T cell | 12 months |
| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
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