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The purpose of this study is to examine if high intensity interval training after stroke is more effective than standard care to increase maximal oxygen uptake, reduce known risk factors for recurrent stroke and improve function.
Stroke is a leading cause of adult disability. Well designed studies have shown that the majority of the stroke population have low aerobic capacity and many are inactive. This is negative for their health and well-being. Physical inactivity may increase their risk of having recurrent stroke.
The optimal training mode and intensity to improve aerobic capacity after stroke are not clear. High intensity interval training (ie. 90-95% of peak heart rate) has been proven to be more beneficial than moderate and low intensity exercise in order to improve maximal oxygen uptake in patients with cardiac disease. The response from this training on aerobic capacity and physical function in the stroke population are not known.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training | Experimental | Supervised high intensity interval training (uphill treadmill walking 4 x 4 min at 90-95% of peak heart rate) 3 times weekly for 8 weeks |
|
| standard care | Other | Standard clinical follow-up care, including general information about importance of physical activity as part of a healthy lifestyle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intensity interval training | Behavioral | Uphill treadmill walking |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal Oxygen Uptake | A graded treadmill test of maximal oxygen uptake using a breath by breath ergospirometer | 1 year after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood pressure (systolic and diastolic) | Blood pressure will be measured at rest | 8 weeks and 12 months after inclusion |
| Walking speed | Walking speed (in minutes:seconds) will be measured with the 10 meter walk test and the Timed Up and Go test. |
| Measure | Description | Time Frame |
|---|---|---|
| New cardiovascular or cerebrovascular incidents | Gathered from the participants and their electronic journal system | 8 weeks and 12 months after inclusion |
| Severity of stroke | The Stroke Impact Scale will be used to evaluate how the stroke has affected the participants' health and life in addition to the National Institute of Health Stroke scale |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Torunn Askim, phd | Norwegian University of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neuroscience | Trondheim | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32145280 | Result | Gjellesvik TI, Becker F, Tjonna AE, Indredavik B, Nilsen H, Brurok B, Torhaug T, Busuladzic M, Lydersen S, Askim T. Effects of High-Intensity Interval Training After Stroke (the HIIT-Stroke Study): A Multicenter Randomized Controlled Trial. Arch Phys Med Rehabil. 2020 Jun;101(6):939-947. doi: 10.1016/j.apmr.2020.02.006. Epub 2020 Mar 4. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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| General information |
| Behavioral |
Standard care |
|
| 8 weeks and 12 months after inclusion |
| Leisure time activity and inactive time | Using the ActivePal monitor attached to the participants non-affected leg information on position, walking and inactive time will be measured during 3 whole consecutive days. | 8 weeks and 12 months after inclusion |
| Balance tested with the Bergs Balance Test | 8 weeks and 12 months after inclusion |
| Change in Blood tests | The following blood tests will be taken: Hemoglobin, HDL, LDL, Cholesterol, Total Cholesterol, C peptides, Triglycerides and HbA1c | 8 weeks and 12 months after inclusion |
| Independence assessed by Functional Independence Measure (FIM) | 8 weeks and 12 months after inclusion |
| Self reported physical activity level assessed by International Physical Activity Questionnaire | 8 weeks and 12 months after inclusion |
| Cognitive function assessed by Montreal Cognitive Assessment and Trail Making A and B | 8 weeks and 12 months after inclusion |
| Walking distance | Walking distance (in meters) will be measured with the 6 minute walk test. | 8 weeks and 12 months after inclusion |
| 8 weeks and 12 months after inclusion |
| Anxiety and depression after stroke | Hospital and Anxiety and Depression Scale will be used to get information about the participants level of anxiety and depression | 8 weeks and 12 months after inclusion |
| Degree of disability and dependence | Modified Rankin Scale (mRS) | 8 weeks and 12 months after inclusion |
| Health status assessed by The Norwegian version of EQ-5D-5L questionnaire | 8 weeks and 12 months after inclusion |
| Submaximal oxygen consumption during treadmill walking | Oxygen consumption will be measured at a standardized speed and inclination. | 8 weeks and 12 months after inclusion |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |