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Nanoparticles (NP) are particles whose length, width and height are less than 100 nanometres. Over the past decade, industrial applications of NP have increased dramatically. Despite their widespread use, their true impact on human health remains unknown and poorly studied. NP exposure in humans primarily occurs via inhalation through the respiratory system. The aim of this study is to estimate the relationships between the nanoparticle load in the lung and bronchi and some interstitial lung diseases. In the aftermath of human exposure to asbestos, the pathological consequences of environmental exposure to nanomaterials could be evaluated upon a mineralogical analysis of pulmonary samples.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Idiopathic interstitial diseases | " Test group ": patients suffering from idiopathic interstitial lung diseases including sarcoidosis and idiopathic pulmonary fibrosis. Nanoparticles (NP) loads will be measured on Bronchoalveolar lavages (BAL), bronchial washings (BW), exhaled air condensates (EAC), blood specimen and urine specimen. |
| |
| Non idiopathic intertitial diseases | " Control group ": patients suffering from interstitial lung diseases of known aetiologies, such as hypersensibility pneumonitis, infectious or cancerous interstitial diseases and interstitial diseases caused by drug reactions. Nanoparticles (NP) loads will be measured on Bronchoalveolar lavages (BAL), bronchial washings (BW), exhaled air condensates (EAC), blood specimen and urine specimen. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BAL | Other | Patients with idiopathic and non idiopathic interstitial lung diseases |
|
| Measure | Description | Time Frame |
|---|---|---|
| NP load | The load of NP is a composite outcome. It will be described according to their level of presence (high, moderate or low), their size and chemical analysis. Analysis: The presence of NP will be assessed by dynamic light scattering (DLS). The elemental compositions of both the particulate (pellet) and the soluble (supernatant) fractions of each sample will be measured by means of inductively coupled plasma optical emission spectroscopy (ICP-OES). The samples for which DLS and ICP-OES corroborated a relatively stronger NP load will be observed under transmission electron microscopy (TEM) and field-emission electron microscopy (FESEM). | day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between NP load in the lung and observed lung interstitial diseases | The load of NP is a composite outcome. It will be described according to their level of presence (high, moderate or low), their size and chemical analysis. The accurate diagnosis of the disease will be determined in accordance to the latest international guidelines, including the past history of each patient, the professional courses with focus on potential NP exposure, environmental studies, tobacco or drug use and exhaustive research of collagen or vascular diseases. |
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Inclusion Criteria:
These patients suffer from:
Written consent
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Michel VERGNON, PhD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Saint-Etienne | Saint-Etienne | 42055 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36541529 | Derived | Marie-Desvergne C, Dubosson M, Leclerc L, Campo C, Bitounis D, Forest V, Pourchez J, Cottier M, Vergnon JM, Tarantini A, Chamel-Mossuz V. Characterization of the elemental and particle load of patient exhaled breath condensate and comparison with pulmonary lavages. J Breath Res. 2022 Dec 15;17(1). doi: 10.1088/1752-7163/aca697. | |
| 34564355 |
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Bronchoalveolar lavages (BAL), bronchial washings (BW), exhaled air condensates (EAC), blood and urine
| BW | Other | Patients with idiopathic and non idiopathic interstitial lung diseases |
|
| EAC | Other | Patients with idiopathic and non idiopathic interstitial lung diseases |
|
| blood specimen | Other | Patients with idiopathic and non idiopathic interstitial lung diseases |
|
| Urine specimen | Other | Patients with idiopathic and non idiopathic interstitial lung diseases |
|
| Day 1 |
| Correlation between NP load in the lung and NP load in blood specimen | The load of NP is a composite outcome. It will be described according to their level of presence (high, moderate or low), their size and chemical analysis. | Day 1 |
| Correlation between NP load in the lung and NP load in urine specimen | The load of NP is a composite outcome. It will be described according to their level of presence (high, moderate or low), their size and chemical analysis. | Day 1 |
| Forest V, Pourchez J, Pelissier C, Audignon Durand S, Vergnon JM, Fontana L. Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases. Toxics. 2021 Aug 30;9(9):204. doi: 10.3390/toxics9090204. |
| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D059349 | Urine Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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