Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction (VITDAMI)

Multicentric, Randomized, Double-blind, Placebo-controlled Clinical Trial to Assess the Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction

To study the effect of calcifediol on left ventricular remodeling, mineral metabolism, plasma levels of several prognostic biomarkers and on endothelial function after an anterior myocardial infarction.

Inclusion Criteria:

• Age ≥ 40 years and maximum 85 years.
• Anterior myocardial infarction
• Sign informed consent

Exclusion Criteria:

• Death during the index event
• Age younger than 40 or older than 85 years
• Previous Infarction
• More than 7 days in hospitalization
• Systemic inflammatory or autoimmune disease
• Concomitant disorders limiting survival
• Concomitant cardiomyopathy
• Left ventricular hypertrophy > 16mm in females and > 17mm in males
• eGFR<45
• LVEF<30
• Incomplete revascularization
• Valvular prosthesis
• Aortic stenosis with mean gradient> 25 mmHg
• Moderate or severe valvular regurgitation
• Hypersensitivity or intolerance vitamin D supplement o excipient
• Blood Calcium >10.5 mg/dl
• Inability to follow.
• Difficulty in treatment compliance
• Contraindication for MRI, including indication to place a cardiac device
• Indication of therapy with vitamin D. Patient desires to take vitamin D.
• Drugs or conditions that interfere with the pharmacokinetics of calcifediol