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| ID | Type | Description | Link |
|---|---|---|---|
| 2011-A00481-40 | Other Identifier | ANSM |
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Bulimic patients suffering from binge eating or "craving" a pressing need to eat, with a sense of unease and anxiety, relieved by food intake. The phenomenon of craving bulimia may be considered appropriately by using paradigms developed in the framework of embodied cognition theories.
In bulimic, a study with 20 bulimic patients proved an automatic attraction (unconscious) for food in these patients, as measured by reaction time.
Moreover, a therapeutic explored in bulimia (particularly on reducing craving), is repeated transcranial magnetic stimulation (rTMS). Studies have shown that a single session of rTMS to the dorsolateral prefrontal cortex left (DLPFC) reduces significantly the food craving among bulimics, 24 hours after stimulation. But the therapeutic efficacy of TMS on bulimia to more than 24 hours has not yet been demonstrated, and the psycho-cognitive underlying mechanisms have not yet been explored.
The exams / treatments of the study include:
Cognitive test consist in , on a computer screen:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| rTMS session | Experimental | Patients will have a 20 minute session of rTMS at a frequency of 10 Hz. |
|
| rTMS placebo (SHAM) session | Placebo Comparator | Patients will have a 20 minute session of placebo rTMS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rTMS session | Device | One session of rTMS at a frequency of 10 Hz during 20 minutes |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Motor response time | time taken to pull or push the lever in cognitive tests (composite measure) | 24h after rTMS session |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Torrance SIGAUD, MD | CHU de SAINT-ETIENNE | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de SAINT-ETIENNE | Saint-Etienne | 42000 | France |
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| ID | Term |
|---|---|
| D002032 | Bulimia |
| ID | Term |
|---|---|
| D006963 | Hyperphagia |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| rTMS Placebo (SHAM) |
| Device |
One session of placebo (SHAM) rTMS during 20 minutes |
|