Clotting With Different Dialyzer Membranes

Pilot Study to Determine the Effect of Different Dialyzer Membranes on Clotting During Haemodiafiltration Treatments in Patients With Chronic Kidney Disease

Primary Objective:

The purpose of this study is to measure the amount of convection achieved with two different haemodiafilters designed for haemodiafiltration and clotting during haemodiafiltration treatment.

This is a prospective observational cohort pilot study of patients under the care of the Royal Free Hospital with chronic kidney disease who have been established on regular thrice weekly haemodiafiltration treatments in a dialysis centre. Information on the study will be disseminated to the Royal Free consultant nephrologists at the dialysis centre with primary responsibility for the individual patient.

Inclusion Criteria:

• Patients age 18 years and older up to 80 years
• Under the care of the Royal Free Hospital with chronic kidney disease and established on regular thrice weekly haemodiafiltration.
• Able to provide written informed consent obtained

Exclusion Criteria:

• Patients scheduled for a kidney transplant
• Patients taking concomitant systemic anticoagulants
• Patients with known prothrombotic or bleeding disorders
• Patients with abnormal platelet counts
• Patients unable to provide written informed consent
• Patients not fulfilling inclusion criteria