The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.

Inclusion Criteria:

• fever;
• presence of absolute neutrophil count <0.5 x 10^9/L
• evidence of bacterial or fungal infections (including clinical signs of infection, positive cultures or biopsy, and radiological evidences)
• unresponsiveness to appropriate antimicrobial therapy for at least 48 hours

Exclusion Criteria:

• none

Adult patients with malignant emopatia who received granulocyte transfusions as adjunctive therapy in the treatment of severe infection, unresponsive to appropriate antimicrobial therapy, which was incurred during neutropenia.