Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia

Efficacy of Granulocyte Transfusions for the Treatment of Severe Infections in Hematological Patients With Febrile Neutropenia

The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.

Inclusion Criteria:

• fever;
• presence of absolute neutrophil count <0.5 x 10^9/L
• evidence of bacterial or fungal infections (including clinical signs of infection, positive cultures or biopsy, and radiological evidences)
• unresponsiveness to appropriate antimicrobial therapy for at least 48 hours

Exclusion Criteria:

• none