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Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS). Mechanical ventilation in the emergency department (ED) has been studied infrequently when compared to the intensive care unit; however, data suggests that ED-based mechanical ventilation has significant room for improvement and may also be a causative factor in ARDS incidence.
This is a before-after study examining the impact of implementing lung protective ventilation in the emergency department.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre-intervention group | mechanically ventilated patients before implementation of ED lung protective ventilation | ||
| Intervention group | mechanically ventilated patients after implementation of ED lung protective ventilation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lung protective ventilation | Procedure | Lung protective ventilation strategy, which aims to deliver safe tidal volumes, appropriate PEEP, limit plateau pressure, and limit hyperoxia. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Patients That Die During the Hospitalization | Patients will be followed for the duration of hospital stay |
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Inclusion Criteria:
Exclusion Criteria:
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mechanically ventilated patients in the emergency department
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| Name | Affiliation | Role |
|---|---|---|
| Brian M Fuller, MD, MSCI | Washington University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Washinton University School of Medicine in St. Louis | St Louis | Missouri | 63110 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29261567 | Derived | Roberts BW, Mohr NM, Ablordeppey E, Drewry AM, Ferguson IT, Trzeciak S, Kollef MH, Fuller BM. Association Between Partial Pressure of Arterial Carbon Dioxide and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department. Crit Care Med. 2018 Mar;46(3):e213-e220. doi: 10.1097/CCM.0000000000002918. | |
| 27067896 |
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| ID | Title | Description |
|---|---|---|
| FG000 | Pre-intervention Group | mechanically ventilated patients before implementation of ED lung protective ventilation |
| FG001 | Intervention Group | mechanically ventilated patients after implementation of ED lung protective ventilation lung protective ventilation: Lung protective ventilation strategy, which aims to deliver safe tidal volumes, appropriate PEEP, limit plateau pressure, and limit hyperoxia. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Pre-intervention Group | mechanically ventilated patients before implementation of ED lung protective ventilation |
| BG001 | Intervention Group | mechanically ventilated patients after implementation of ED lung protective ventilation lung protective ventilation: Lung protective ventilation strategy, which aims to deliver safe tidal volumes, appropriate PEEP, limit plateau pressure, and limit hyperoxia. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department | Posted | Number | participants | 7 days |
|
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Pre-intervention Group | mechanically ventilated patients before implementation of ED lung protective ventilation |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Brian M Fuller | Washington University in St. Louis | 3147475368 | fullerb@wustl.edu |
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| Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH. Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications. BMJ Open. 2016 Apr 11;6(4):e010991. doi: 10.1136/bmjopen-2015-010991. |
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
| Secondary | Number of Patients That Die During the Hospitalization | Posted | Number | participants | Patients will be followed for the duration of hospital stay |
|
|
|
| 0 |
| 1,192 |
| 0 |
| 1,192 |
| EG001 | Intervention Group | mechanically ventilated patients after implementation of ED lung protective ventilation lung protective ventilation: Lung protective ventilation strategy, which aims to deliver safe tidal volumes, appropriate PEEP, limit plateau pressure, and limit hyperoxia. | 0 | 513 | 0 | 513 |
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