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| Name | Class |
|---|---|
| Mount Sinai Hospital, Montreal | OTHER |
| Laval University | OTHER |
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This is a multi-site collaborative study that will be done in the context of three Quebec hospitals' outpatient pulmonary rehabilitation programs: Montreal Chest Institute; University of Laval, and Hopital Sacre-Coeur Montreal. The objectives are two-fold. First, to determine the Minimal Clinical Important Difference in intensity ratings of perceived breathlessness for each of the 3-min constant rate shuttle walking (3-MWT) and stair stepping (3-MST) protocols in patients with chronic obstructive pulmonary disease (COPD). Second, to test the hypothesis that both the 3-MWT and 3-MST protocols are able to detect statistically significant and clinically-meaningful improvements in exertional breathlessness following an 7-12 week outpatient rehabilitative exercise training program in COPD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pulmonary Rehabilitation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pulmonary Rehabilitation | Other | Patients will participate in 3 exercise training sessions/wk for a period of 7-12 wks at one of 4 sites in Quebec. Each training session will include 30-45 min of aerobic training (cycling and/or treadmill walking) at a target intensity of 80% of the maximal heart rate achieved during a symptom-limited incremental cycle exercise test performed prior to the pulmonary rehabilitation program; and 20-30 min of strength training exercises. |
| Measure | Description | Time Frame |
|---|---|---|
| Minimal clinically important difference (MCID) with regards to the change in breathlessness intensity ratings at the end of each of the 3-MST and 3-MWT. | Baseline and 7 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change (post- minus pre- pulmonary rehab) in dyspnea intensity ratings on the Borg 0-10 ratio category scale | Borg 0-10 category ratio scale | Baseline and 7 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change (post- minus pre- pulmonary rehab) in spirometry (FEV1, FVC, and FEV1/FVC) | expressed in L and as % predicted | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in lung volumes (TLC, FRC, RV) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dennis Jensen, Ph.D. | Contact | 514-398-4184 | 0541 | dennis.jensen@mcgill.ca |
| Name | Affiliation | Role |
|---|---|---|
| Dennis Jensen, Ph.D. | McGill University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| McConnell Centre for Innovative Medicine, Research Institute of the McGill University Health Centre | Recruiting | Montreal | Quebec | H4A 3J1 | Canada |
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| Label | URL |
|---|---|
| Clinical Exercise \& Respiratory Physiology Laboratory (CERPL) of McGill University | View source |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D004417 | Dyspnea |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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|
expressed in L and as % predicted
| Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in airways resistance (Raw, sRaw) | expressed in L and as % predicted | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) CCQ | questionnaire | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) CRQ | questionnaire | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) IPAQ | questionnaire | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) BDI/TDI | questionnaire | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) CAT | questionnaire | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in Exercise Endurance Time (EET) to constant power output cycling exercise performed at 75% of the peak incremental cycling power output achieved prior to start of pulmonary rehab | EET, in minutes and sec | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in peak VO2 to constant power output cycling exercise performed at 75% of the peak incremental cycling power output achieved prior to start of pulmonary rehab | in ml/kg/min and as %predicted | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in peak Ventilation to constant power output cycling exercise performed at 75% of the peak incremental cycling power output achieved prior to start of pulmonary rehab | in L/min, as %predicted and as % of MVV (=FEV1x35) | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in the 6-minute walk distance | in m | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in body composition assessed by dual-energy X-ray absorptiometry | Lean body mass (g) | Baseline and 7 weeks |
| Change (post- minus pre- pulmonary rehab) in isometric quadriceps peak torque | % predicted | Baseline and 7 weeks |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |