Dopamine Receptor Agonist Therapy for Pain Relief in Women Suffering From Endometriosis: A Pilot Study

Dopamine Receptor Agonist Therapy for Pain Relief in Women Suffering From Endometriosis: A Pilot Study

The proposed pilot study will estimate the efficacy and safety of a novel therapeutic agent, cabergoline, with a clinical standard therapy, norethindrone acetate, for the treatment of endometriosis-associated pain in young women with endometriosis.

Inclusion Criteria:

• Surgically confirmed endometriosis
• Age between 15-40 y, and premenopausal
• Pelvic pain score ≥3 on a Visual Analog Scaleover the last month

Exclusion Criteria:

• Use of other concurrent hormone medications (such as birth control pills)
• Impaired liver function (ALT > 2x normal) or liver disease (cirrhosis, hepatitis)
• Pregnancy
• Breast cancer
• Active thromboembolic disease
• Uncontrolled hypertension, history of cardiac valve disorder, history of fibrotic disorders