Hypertonic Saline Resuscitation in Trauma Patients After Hemorrhage Control

Hypertonic Saline Resuscitation for Early Closure of Open Abdomen in Trauma Patients

This study aimed to determine whether hypertonic saline solution is effective in the resuscitation of injured patients undergoing abdominal damage control surgery regarding early closure of the abdominal wall.

A double-blind, controlled, randomized clinical trial was conducted to determine the impact of an infusion of hypertonic saline 3% vs. isotonic saline 0.9% at a dose of 50 mL/hr for the first 72 hours in patients with abdominal trauma requiring damage control surgery regarding some clinically relevant outcomes. These outcomes were: The timing of abdominal cavity closure, fluids balance, abdominal hypertension, and abdominal compartment syndrome occurrence, organ dysfunction, and 28 days' mortality.

Inclusion Criteria:

• Abdominal trauma requiring damage control surgery.
• Acceptance by the patient or by a proxy to be included in the trial.

Exclusion Criteria:

• Concomitant severe head trauma, defined by a Glasgow score <9, before receiving sedation or by the presence of cerebral edema or intracranial injury on a CT-scan.
• Pregnancy
• Patient not included 4 hours or more after damage control surgery.
• Damage control laparotomy performed for other indications other than trauma.
• Not index damage control laparotomy
• No acceptance to participate in the study.