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| Name | Class |
|---|---|
| University College London Hospitals | OTHER |
| Cambridge University Hospitals NHS Foundation Trust | OTHER |
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The main aim is to develop and test the clinical efficacy of a novel, web based, rehabilitation application. Listen-In will provide an effective speech comprehension training tool that patients with aphasia can use to practice independently. This will free up therapists time to provide additional assessment, supervision and functional intervention in a highly cost effective manner.
The main aim is to develop and test the clinical efficacy of a novel, web based, rehabilitation application. Listen In will provide an effective speech comprehension training tool that patients can use to practice independently. This will free up SALT time to provide additional assessment, supervision and functional intervention in a highly cost effective manner.
Phase 1 (24 months. London, Newcastle, Cambridge): Development of Listen In, including diagnostic and therapeutic components, driven by patient user's feedback (alpha and beta testing). The intervention is detailed below and is based on current SALT practice. It will be adaptive, provide feedback and target auditory perception at many levels: the phonemic, lexical and sentence level processing of heard verbal stimuli, as well as auditory short term memory and nonverbal sound discrimination.
Phase 2 (12 months. London and Cambridge): A pilot, randomised, crossover, clinical trial of Listen-In in a group of aphasic patients in the chronic post-stroke period. A power calculation suggests that we will need 36 patents, 18 in each arm. The comparison will be standard SALT clinical care. The main outcome measure is a clinically relevant improvement on the comprehension of spoken language score of the Comprehensive Aphasia Test (Swinburn, 2004). Secondary outcomes include improvements in social activity and participation. The milestones for this phase will be: 50% recruitment into study and last patient, last visit.
Phase 3 (funded outside i4i grant) will be the rollout of the therapy application on the internet with a pragmatic trial of whether therapy gains can be made outside the confines of a clinical trial. The comparison will be on similar outcome measures as Phase 2 with a control test on sustained attention (internal control) that we predict will not improve with therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| trial arm | Experimental | 100 hours of therapy. |
|
| Normal therapy arm | No Intervention | 12 weeks of normal therapy. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Auditory comprehension therapy. | Behavioral | 100 hours of Auditory comprehension therapy embedded within a computer game. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in auditory comprehension on the comprehensive aphasia test. | Investigation of improvement on a functionally relevant area of a widely used test of aphasia. | Measured over 36 weeks (0,12,24,36) weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in functional communication | Using patient reported outcomes to look at functional communication changes. | Measured over 36 weeks (0,12,24,36) weeks |
| Improvement in production of language |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alex Leff, PhD | ucl | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCLondon | London | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33154182 | Derived | Fleming V, Brownsett S, Krason A, Maegli MA, Coley-Fisher H, Ong YH, Nardo D, Leach R, Howard D, Robson H, Warburton E, Ashburner J, Price CJ, Crinion JT, Leff AP. Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging. J Neurol Neurosurg Psychiatry. 2020 Nov 5;92(4):418-24. doi: 10.1136/jnnp-2020-324256. Online ahead of print. |
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| ID | Term |
|---|---|
| D001037 | Aphasia |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
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Investigation of improvement on a functionally relevant area of a widely used test of aphasia.
| Measured over 36 weeks (0,12,24,36) weeks |
| Performance on the Sustained attention to response task | Investigation of improvement on sustained attention using the SART. | Measured over 36 weeks (0,12,24,36) weeks |
| Environmental sounds test | Investigation of improvement on the non verbal environmental sounds test. | Measured over 36 weeks (0,12,24,36) weeks |
| Test of semantics | Investigation of improvement in semantics knowledge. | Measured over 36 weeks (0,12,24,36) weeks |
| Improvement in written language comprehension | Investigation of improvement on a functionally relevant area of a widely used test of aphasia. | Measured over 36 weeks (0,12,24,36) weeks |
| Improvement on auditory descrimination | Investigation of improvement on a test of auditory discrimination developed by Dr Holly Robson. | Measured over 36 weeks (0,12,24,36) weeks |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |