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Although adequate bowel preparation is essential for successful colonoscopy, the 23% of patients had shown inadequate bowel preparation. Inadequate bowel preparation may results in incomplete examination, increased patient's discomfort, decreased polyp detection rates, ultimately leading to repeated colonoscopies. One prior study showed that patients reporting their last rectal effluents as brown color or solid stool had a 54% chance of having fair or poor preparation. Thus, recent consensus guideline suggested consideration of additional oral preparation in patients presenting brown effluents on the day of colonoscopy. However, the data supporting additional oral preparation is still spares. Therefore, the investigators aimed to examine the impact of additional oral preparation on the quality of bowel preparation for colonoscopy in patients showing brown effluents on the day of colonoscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Additional oral preparation | Experimental | The investigational or experimental arm will receive standard oral preparation plus additional oral preparation (1l of polyethylene glycol (PEG)+ascorbic acid (Asc)) for colonoscopy. * Compositions/1L : Sodium Chloride 2.691g Potassium Chloride 1.015g Anhydrous sodium sulfate 7.5g PEG 3350 100g ascorbic acid 4.7g sodium ascorbate 5.9g |
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| Standard oral preparation | Active Comparator | The control arm will receive currently used oral preparation (2L of polyethylene glycol+ascorbic acid) for colonoscopy. * Compositions/1L : Sodium Chloride 2.691g Potassium Chloride 1.015g Anhydrous sodium sulfate 7.5g PEG 3350 100g ascorbic acid 4.7g sodium ascorbate 5.9g |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Additional oral preparation (3L of PEG+Asc, "Coolprep®") | Drug | The interventional or experimental arm will receive 1l of additional PEG+Asc, "Coolprep®" on the day of colonoscopy * Compositions/1L : Sodium Chloride 2.691g Potassium Chloride 1.015g Anhydrous sodium sulfate 7.5g PEG 3350 100g ascorbic acid 4.7g sodium ascorbate 5.9g |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of bowel preparation | The primary outcome will be the endoscopist's assessment of the quality of preparation using a standardized bowel preparation scale | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Adenoma detection rate | Number of adenomatous polyps | Day 1 |
| Patient compliance | Patient compliance with preparation instructions self-reported in a pre-procedure questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eun Soo Kim | Keimyung University Dongsan Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Keimyung University Dongsan Medical Center | Daegu | 700-712 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20362286 | Result | Fatima H, Johnson CS, Rex DK. Patients' description of rectal effluent and quality of bowel preparation at colonoscopy. Gastrointest Endosc. 2010 Jun;71(7):1244-1252.e2. doi: 10.1016/j.gie.2009.11.053. Epub 2010 Apr 1. |
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| Standard oral preparation (2L of PEG+Asc, "Coolprep®") | Drug | The control arm will receive currently used oral preparation (2l of PEG+Asc, "Coolprep®") for colonoscopy * Compositions/1L : Sodium Chloride 2.691g Potassium Chloride 1.015g Anhydrous sodium sulfate 7.5g PEG 3350 100g ascorbic acid 4.7g sodium ascorbate 5.9g |
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| Baseline |
| Patient satisfaction | Patient's perception of the preparation method as self-reported on a pre-procedure questionnaire. | Baseline |