Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Jazz Pharmaceuticals | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Despite the current available therapies for opioid-dependent patients, most patients relapse. This research project focuses on the development of a novel compound, cannabidiol, to modulate opioid craving in humans based on animal models showing its selective effectiveness to inhibit drug-seeking behavior. The development of a targeted treatment for opioid relapse would be of tremendous medical and public health value.
There has been an epidemic rise in heroin abuse and overdose in recent years. Of the more than one million people suffering today from opiate dependency, less than a quarter of such individuals receive treatment. Pharmacotherapeutic approaches traditionally have targeted mu opioid receptors since heroin and its metabolites bind with highest affinity to this receptor subtype. Although such treatment strategies have improved substance abuse outcomes, they do not effectively block opiate craving and thus are still associated with high rates of relapse. Using a strategy of indirectly regulating neural systems to modulate opioid-related behavior, our preclinical rodent studies consistently demonstrated that cannabidiol (CBD), a nonpsychoactive component of cannabis, specifically inhibited cue-induced heroin-seeking behavior. CBD's selective effect on drug-seeking behavior was pronounced after 24 hrs and endured even two weeks after the last drug administration following short-term CBD exposure. The fact that drug craving is generally triggered by exposure to conditioned cues suggests that CBD might be an effective treatment for heroin craving, specially given its protracted impact on behavior. CBD has already been shown in Phase I of our study and in various clinical studies to be well tolerated with a wide safety margin in human subjects. CBD thus represents a strong candidate for the development as a potential therapeutic agent in humans for opioid craving and relapse prevention. Preliminary pilot study showed CBD decreased craving. It is the goal of the current study to more fully characterize the effects of CBD administration on cue-induced craving in drug-abstinent heroin-dependent subjects using a random double blind design during a post-acute (greater than 6 days since last use) heroin withdrawal period. Study participants will be administered CBD during 3 test sessions and studied for the effects on cue-induced craving during those sessions as well as one week after the final CBD administration on the final test day (session 4).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Subjects will receive a solution that resemble the Cannabidiol solution but do not have have its properties |
|
| CBD 400mg | Experimental | Subjects will receive 400mg of cannabidiol |
|
| CBD 800mg | Experimental | Subjects will receive 800 mg of cannabidiol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CBD 400 mg | Drug | Subjects in Arm CBD 400 mg will receive 400mg of Cannabidiol in each of the three test sessions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Cue-Induced In-Clinic Craving (From Baseline to Post-cue (30 Minutes), and From Test Day 1 Through Test Day 4 (1 Week)) - Via the Visual Analog Scale for Craving (VASC) | The VASC will be administered to assess potential variations in the subjective craving effects associated with heroin. Following the administration of the investigational drug, craving induced in response to the cue sessions in the clinic will be measured. Note, cue sessions occur consecutively in the same test day. In this way, changes in craving from baseline (pre-cue to post-cue within each test day), as well as changes in cue-induced craving over the short-term (test day 1 through test day 4 a week later) will be monitored and measured. VASC scale ranges from 0 for "Not Craving at All" to 10 for "Extremely Craving." | VASC: test day I, II and IV - at arrival, baseline for cue 1 and 2, post-cue 1 and 2, before discharge (approximately 2.5 hours from session start on average); test day III: at arrival and discharge (approx. 2.5 hours from session start on average) |
| Changes in Out-of-Clinic Craving (From Pre-dose to Approximately 4-6 Hours Post-dose; and From Test Day 1 to Test Day 4 or 1 Week) - Via the Heroin Craving Questionnaire (HCQ) | Subjects will be asked to complete the short version of the HCQ on their own time at home and bring it with them when they return for their next visit. Upon arrival to the clinic, subjects will also complete an HCQ with the coordinator to assess daily baseline cravings. This questionnaire will help us assess changes in craving generated outside of the clinical laboratory session from test day 1 through test day 4 (1 week later). Each item is scored on a scale ranging from 1 for "Strongly Disagree" to 7 for "Strongly Agree." Sum of all 14 items are scored and added. Mean scores reported below. Total Score Range: 14 (less cravings) - 98 (more cravings). | HCQ: once in clinic pre-dose at each test day, and once at home after each test day. |
| Measure | Description | Time Frame |
|---|---|---|
| Vital Signs | Blood pressure (in mmHg), heart rate (in beats/min), temperature (in degrees Fahrenheit), respiratory rate (in breaths/min), and O2 saturation and pain will be monitored throughout the time course of the study and changes from baseline will be studied across the various time points. Note, cue sessions occur consecutively in the same test day. Results reported below are responses from baseline following exposure to neutral and heroin-associated cues in Session 1 in subjects with CBD or placebo administration. |
| Measure | Description | Time Frame |
|---|---|---|
| CBD Effects on Cognitive Behavior | Digit Span Backwards (DSB) is a memory task consisting of a span of digits recalled in reverse order. Participants are read a series of digits (e.g., 4,7,1) and must immediately repeat them back in reverse order (e.g., 1,7,4). Mean correct response times (hits) are reported below in milliseconds. Shorter response times indicate better participant outcomes. Digit Symbol Substitution Task (DSST) is a neuropsychological test consisting of digit-symbol pairs.The goal is to complete as many correct patterns as possible in 3 mins. Mean response times reported below in ms, with shorter times indicating better outcomes. |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Yasmin Hurd, PhD | Mount Sinai Health System | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mount Sinai Beth Israel | New York | New York | 10003 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31109198 | Derived | Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E. Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial. Am J Psychiatry. 2019 Nov 1;176(11):911-922. doi: 10.1176/appi.ajp.2019.18101191. Epub 2019 May 21. |
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | Control | Subjects will receive a solution that resemble the Cannabidiol solution but do not have have its properties Control (placebo): Subjects will receive a harmless, inactive solution to compare and validate the results of the other arms of the study |
| FG001 | CBD 400mg | Subjects will receive 400mg of cannabidiol CBD 400 mg: Subjects in Arm CBD 400 mg will receive 400mg of Cannabidiol in each of the three test sessions |
| FG002 | CBD 800mg | Subjects will receive 800 mg of cannabidiol CBD 800 mg: Subjects in Arm CBD 800 mg will receive 800mg of Cannabidiol in each of the three test sessions |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Control | Subjects will receive a solution that resemble the Cannabidiol solution but do not have have its properties Control (placebo): Subjects will receive a harmless, inactive solution to compare and validate the results of the other arms of the study |
| BG001 | CBD 400mg |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Changes in Cue-Induced In-Clinic Craving (From Baseline to Post-cue (30 Minutes), and From Test Day 1 Through Test Day 4 (1 Week)) - Via the Visual Analog Scale for Craving (VASC) | The VASC will be administered to assess potential variations in the subjective craving effects associated with heroin. Following the administration of the investigational drug, craving induced in response to the cue sessions in the clinic will be measured. Note, cue sessions occur consecutively in the same test day. In this way, changes in craving from baseline (pre-cue to post-cue within each test day), as well as changes in cue-induced craving over the short-term (test day 1 through test day 4 a week later) will be monitored and measured. VASC scale ranges from 0 for "Not Craving at All" to 10 for "Extremely Craving." | Posted | Mean | Standard Error | units on a scale | VASC: test day I, II and IV - at arrival, baseline for cue 1 and 2, post-cue 1 and 2, before discharge (approximately 2.5 hours from session start on average); test day III: at arrival and discharge (approx. 2.5 hours from session start on average) |
|
Adverse events were collected during the course of study participation, approx. 2 weeks.
Adverse events were collected by using SAFTEE (Systematic Assessment for Treatment Emergent Events)
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Control | Subjects will receive a solution that resemble the Cannabidiol solution but do not have have its properties Control (placebo): Subjects will receive a harmless, inactive solution to compare and validate the results of the other arms of the study |
Not provided
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Headache | Nervous system disorders | Systematic Assessment |
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Yasmin Hurd, PhD | Icahn School of Medicine at Mount Sinai | 212 824 9314 | yasmin.hurd@mssm.edu |
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Mar 12, 2017 | Feb 7, 2022 | Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Mar 12, 2017 | Feb 7, 2022 | SAP_001.pdf |
Not provided
| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| CBD 800 mg | Drug | Subjects in Arm CBD 800 mg will receive 800mg of Cannabidiol in each of the three test sessions |
|
|
| Control (placebo) | Drug | Subjects will receive a harmless, inactive solution to compare and validate the results of the other arms of the study |
|
|
| Pre-placebo/drug, -60 min pre-cue, -40 min pre-cue, -20 min pre-cue, cue (time 0), 15 min post-cue, 35 min post-cue, 50 min post-cue, 65 min post-cue, 85 min post-cue |
| 2 times: once at pre-screening and once at test day 4, within 2 weeks of each other. |
| Visual Analog Scale for Anxiety (VASA) | Questionnaires will be used to measure subjective responses. Anxiety will be assessed using a visual analog scale for anxiety (VASA). VASA scale ranges from 0 for "Not Anxious at All" to 10 for "Extremely Anxious." Note, cue sessions occur consecutively in the same test day. | Test day I, II and IV: on arrival, baseline for cue sessions 1 and 2, post-cue sessions I and 2 (30 min from baseline), prior to discharge (approximately 2.5 hours from test day start on average); Test day III: on arrival and prior to discharge. |
| The Positive and Negative Affect Schedule(PANAS) | Questionnaires will be used to measure subjective responses. The Positive and Negative Affect Schedule will allow us to obtain positive and negative affect measures and observe their changes from baseline over the course of the cue-induced craving session. Note, cue sessions occur consecutively in the same test day. Positive affect scores range from 10 - 50. Higher scores represent higher levels of positive affect. Negative affect scores range from 10 - 50. Higher scores represent high levels of negative affect. | Baseline for cue sessions 1 and 2, post-cue sessions I and 2 (30 min from baseline) during test days I, II and IV. |
| Physiological Response to Stress - Salivary Cortisol Measures | Subjects will be asked to chew on a cotton swab, each time providing us with a saliva sample from which we can detect free cortisol levels and extrapolate serum levels of the stress indicator affected by the video cues. Note, cue sessions occur consecutively in the same test day. Thus, the physiological stress of craving will be monitored and measured across the multiple time points to observe any changes from baseline. Results reported below are mean percent change from baseline following exposure to neutral and heroin-associated cues in Session 1 in subjects with CBD or placebo administration. | Test day I: 15 min and 35 min post drug and neutral cue |
| Adverse Effects - SAFTEE | Before being sent home, subjects will be asked to complete the Systematic Assessment for Treatment of Emergent Events (SAFTEE) to ensure that they are not experiencing any negative effects of the treatment. There will also be a debriefing period at the end of each session aimed to minimize any potential increase in craving beyond the clinical laboratory session. At the end of the last study, subjects will be assessed and offered appropriate resources and guidance for seeking help for substance abuse or cravings should they need it after participation in the study has concluded. | Test day I, II, III and IV: at the end of day prior to discharge. Average time point: approximately 150 minutes into the test day. |
| CBD Effects on Cognitive Behavior | Continuous Performance Test is a computerized assessment of attention. The outcome measures include correct responses (hits), missed responses (misses), incorrect responses (false hits), correct misses, and reaction time of both hits and misses. Mean correct response times (hits) are reported below. Shorter response times indicate better participant outcomes. | 2 times: once at pre-screening and once at test day 4, within 2 weeks of each other. |
Subjects will receive 400mg of cannabidiol CBD 400 mg: Subjects in Arm CBD 400 mg will receive 400mg of Cannabidiol in each of the three test sessions |
| BG002 | CBD 800mg | Subjects will receive 800 mg of cannabidiol CBD 800 mg: Subjects in Arm CBD 800 mg will receive 800mg of Cannabidiol in each of the three test sessions |
| BG003 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race/Ethnicity, Customized | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| OG000 |
| Control |
Subjects will receive a solution that resemble the Cannabidiol solution but do not have have its properties Control (placebo): Subjects will receive a harmless, inactive solution to compare and validate the results of the other arms of the study |
| OG001 | CBD 400mg | Subjects will receive 400mg of cannabidiol CBD 400 mg: Subjects in Arm CBD 400 mg will receive 400mg of Cannabidiol in each of the three test sessions |
| OG002 | CBD 800mg | Subjects will receive 800 mg of cannabidiol CBD 800 mg: Subjects in Arm CBD 800 mg will receive 800mg of Cannabidiol in each of the three test sessions |
|
|
| Primary | Changes in Out-of-Clinic Craving (From Pre-dose to Approximately 4-6 Hours Post-dose; and From Test Day 1 to Test Day 4 or 1 Week) - Via the Heroin Craving Questionnaire (HCQ) | Subjects will be asked to complete the short version of the HCQ on their own time at home and bring it with them when they return for their next visit. Upon arrival to the clinic, subjects will also complete an HCQ with the coordinator to assess daily baseline cravings. This questionnaire will help us assess changes in craving generated outside of the clinical laboratory session from test day 1 through test day 4 (1 week later). Each item is scored on a scale ranging from 1 for "Strongly Disagree" to 7 for "Strongly Agree." Sum of all 14 items are scored and added. Mean scores reported below. Total Score Range: 14 (less cravings) - 98 (more cravings). | Posted | Mean | 95% Confidence Interval | units on a scale | HCQ: once in clinic pre-dose at each test day, and once at home after each test day. |
|
|
|
| Secondary | Vital Signs | Blood pressure (in mmHg), heart rate (in beats/min), temperature (in degrees Fahrenheit), respiratory rate (in breaths/min), and O2 saturation and pain will be monitored throughout the time course of the study and changes from baseline will be studied across the various time points. Note, cue sessions occur consecutively in the same test day. Results reported below are responses from baseline following exposure to neutral and heroin-associated cues in Session 1 in subjects with CBD or placebo administration. | Posted | Mean | Standard Deviation | beats per minute | Pre-placebo/drug, -60 min pre-cue, -40 min pre-cue, -20 min pre-cue, cue (time 0), 15 min post-cue, 35 min post-cue, 50 min post-cue, 65 min post-cue, 85 min post-cue |
|
|
|
| Other Pre-specified | CBD Effects on Cognitive Behavior | Digit Span Backwards (DSB) is a memory task consisting of a span of digits recalled in reverse order. Participants are read a series of digits (e.g., 4,7,1) and must immediately repeat them back in reverse order (e.g., 1,7,4). Mean correct response times (hits) are reported below in milliseconds. Shorter response times indicate better participant outcomes. Digit Symbol Substitution Task (DSST) is a neuropsychological test consisting of digit-symbol pairs.The goal is to complete as many correct patterns as possible in 3 mins. Mean response times reported below in ms, with shorter times indicating better outcomes. | Posted | Mean | Standard Deviation | units on a scale (ms) | 2 times: once at pre-screening and once at test day 4, within 2 weeks of each other. |
|
|
|
| Other Pre-specified | Visual Analog Scale for Anxiety (VASA) | Questionnaires will be used to measure subjective responses. Anxiety will be assessed using a visual analog scale for anxiety (VASA). VASA scale ranges from 0 for "Not Anxious at All" to 10 for "Extremely Anxious." Note, cue sessions occur consecutively in the same test day. | Posted | Mean | Standard Error | score on a scale | Test day I, II and IV: on arrival, baseline for cue sessions 1 and 2, post-cue sessions I and 2 (30 min from baseline), prior to discharge (approximately 2.5 hours from test day start on average); Test day III: on arrival and prior to discharge. |
|
|
|
| Other Pre-specified | The Positive and Negative Affect Schedule(PANAS) | Questionnaires will be used to measure subjective responses. The Positive and Negative Affect Schedule will allow us to obtain positive and negative affect measures and observe their changes from baseline over the course of the cue-induced craving session. Note, cue sessions occur consecutively in the same test day. Positive affect scores range from 10 - 50. Higher scores represent higher levels of positive affect. Negative affect scores range from 10 - 50. Higher scores represent high levels of negative affect. | Posted | Mean | Standard Deviation | score on a scale | Baseline for cue sessions 1 and 2, post-cue sessions I and 2 (30 min from baseline) during test days I, II and IV. |
|
|
|
| Other Pre-specified | Physiological Response to Stress - Salivary Cortisol Measures | Subjects will be asked to chew on a cotton swab, each time providing us with a saliva sample from which we can detect free cortisol levels and extrapolate serum levels of the stress indicator affected by the video cues. Note, cue sessions occur consecutively in the same test day. Thus, the physiological stress of craving will be monitored and measured across the multiple time points to observe any changes from baseline. Results reported below are mean percent change from baseline following exposure to neutral and heroin-associated cues in Session 1 in subjects with CBD or placebo administration. | Posted | Mean | Standard Error | mean percent change | Test day I: 15 min and 35 min post drug and neutral cue |
|
|
|
| Other Pre-specified | Adverse Effects - SAFTEE | Before being sent home, subjects will be asked to complete the Systematic Assessment for Treatment of Emergent Events (SAFTEE) to ensure that they are not experiencing any negative effects of the treatment. There will also be a debriefing period at the end of each session aimed to minimize any potential increase in craving beyond the clinical laboratory session. At the end of the last study, subjects will be assessed and offered appropriate resources and guidance for seeking help for substance abuse or cravings should they need it after participation in the study has concluded. | Posted | Number | events | Test day I, II, III and IV: at the end of day prior to discharge. Average time point: approximately 150 minutes into the test day. |
|
|
|
| Other Pre-specified | CBD Effects on Cognitive Behavior | Continuous Performance Test is a computerized assessment of attention. The outcome measures include correct responses (hits), missed responses (misses), incorrect responses (false hits), correct misses, and reaction time of both hits and misses. Mean correct response times (hits) are reported below. Shorter response times indicate better participant outcomes. | Posted | Mean | Standard Deviation | units on a scale (hits) | 2 times: once at pre-screening and once at test day 4, within 2 weeks of each other. |
|
|
|
| 0 |
| 15 |
| 0 |
| 15 |
| 3 |
| 15 |
| EG001 | CBD 400mg | Subjects will receive 400mg of cannabidiol CBD 400 mg: Subjects in Arm CBD 400 mg will receive 400mg of Cannabidiol in each of the three test sessions | 0 | 14 | 0 | 14 | 4 | 14 |
| EG002 | CBD 800mg | Subjects will receive 800 mg of cannabidiol CBD 800 mg: Subjects in Arm CBD 800 mg will receive 800mg of Cannabidiol in each of the three test sessions | 0 | 13 | 0 | 13 | 5 | 13 |
| Joint Pain | Musculoskeletal and connective tissue disorders | Systematic Assessment |
|
| Tired/Fatigue | Nervous system disorders | Systematic Assessment |
|
| Chest Pain | Cardiac disorders | Systematic Assessment |
|
| Eye Irritation | Eye disorders | Systematic Assessment |
|
| Abdominal Discomfort | Gastrointestinal disorders | Systematic Assessment |
|
| Diarrhea | Gastrointestinal disorders | Systematic Assessment |
|
Not provided
Not provided
| Session 1: Post (At Home) |
|
| Session 2: Pre Drug/Placebo (Day 2 Baseline) |
|
| Session 2 Post (At Home) |
|
| Session 3: Pre Drug/Placebo (Day 3 Baseline) |
|
| Session 3 Post (At Home) |
|
| Session 4: Drug/Placebo (Day 4 Baseline) |
|
|
| Session 1 -40 min pre-neutral cue |
|
| Session 1 -20 min pre-neutral cue |
|
| Session 1 cue (time 0) pre-neutral cue |
|
| Session 1 15 min post-neutral cue |
|
| Session 1 35 min post-neutral cue |
|
| Session 1 50 min post-neutral cue |
|
| Session 1 65 min post-neutral cue |
|
| Session 1 85 min post-neutral cue |
|
| Session 1 baseline pre-drug cue |
|
| Session 1 -60 min pre-drug cue |
|
| Session 1 -40 min pre-drug cue |
|
| Session 1 -20 min pre-drug cue |
|
| Session 1 cue (time 0) pre-drug cue |
|
| Session 1 15 min post-drug cue |
|
| Session 1 35 min post-drug cue |
|
| Session 1 50 min post-drug cue |
|
| Session 1 65 min post-drug cue |
|
| Session 1 85 min post-drug cue |
|
| Digit Symbol Substitution Test (DSST) - Test Day 4 Response Time (ms) |
|
| Digit-Span Backwards (DSB) - Pre·Screen Response Time (ms) |
|
| Digit-Span Backwards (DSB) - Test Day 4 Response Time (ms) |
|
|
| First Baseline (before cue video) Session 4 |
|
| First Post Cue Session 1 |
|
| First Post Cue Session 2 |
|
| First Post Cue Session 4 |
|
| Second Base Line (before cue video) Session 1 |
|
| Second Base Line (before cue video) Session 2 |
|
| Second Base Line (before cue video) Session 4 |
|
| Second Post Cue Session 1 |
|
| Second Post Cue Session 2 |
|
| Second Post Cue Session 4 |
|
| Post Relaxation video Session 1 |
|
| Post Relaxation video Session 2 |
|
| Post Relaxation video Session 4 |
|
|
| Session 2 Neutral Cue Positive PANAS |
|
| Session 2 Drug Cue Positive PANAS |
|
| Session 3 Neutral Cue Positive PANAS |
|
| Session 3 Drug Cue Positive PANAS |
|
| Session 1 Neutral Cue Negative PANAS |
|
| Session 1 Drug Cue Negative PANAS |
|
| Session 2 Neutral Cue Negative PANAS |
|
| Session 2 Drug Cue Negative PANAS |
|
| Session 3 Neutral Cue Negative PANAS |
|
| Session 3 Drug Cue Negative PANAS |
|
|
| Drug Cue 15 min |
|
| Drug Cue 35 min |
|
| Title | Measurements |
|---|---|
|
| Tired/Fatigue |
|
| Chest Pain |
|
| Eye Irritation |
|
| Abdominal Discomfort |
|
| Diarrhea |
|
| Continuous Performance Task (CPT) - Test Day 4 Correct Responses (hits) |
|