A Study of BMS-986171 in Healthy People to Assess Safety, to Measure Blood Levels of Drug, and to Find Out What the Drug Does to the Body

A Randomized, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986171 in Healthy Subjects

The purpose of this study is to assess safety, to measure blood levels of drug, and to find out what the drug does to the body.

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com

Inclusion Criteria:

• Age 21 to 55 years (Part A,B, and C)
• BMI 30-40 (Part A or Part B); BMI 20-35 (Part C). BMI = weight (kg)/ [height (m)]

Exclusion Criteria:

• Any significant medical illness
• Cannot tolerate subcutaneous injections, or having blood samples taken
• Smoking more than 10 cigarettes/day
• History of allergy to pegylated compounds or of hypersensitivity to protein based therapeutics.
• HIV, Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infection.
• Pregnancy