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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-A01372-37 | Other Identifier | ANSM |
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Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm. The directed forgetting paradigm is used, composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
Researchers used the directed forgetting paradigm composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients group 1 | Experimental | Memorization of the verbs by miming the action |
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| Patients group 2 | Experimental | Memorization of the verbs by imagining the action |
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| Patients group 3 | Experimental | Memorization of the action verbs by means of another word |
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| Patients group 4 | Experimental | Simple memorization of the verbs |
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| Healthy volonteers group 1 | Active Comparator | Memorization of the verbs by miming the action |
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| Healthy volonteers group 2 | Active Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Memorization of the verbs by miming the action | Other | The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb. |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of items recalled TBR and TBF | It is asked to the participants to recall orally, only TBR verbs (task of reminder). The experimenter notes the given verbs. | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of recognized items | Participants must recognize TBR verbs among several verbs (distractor or TBF verbs) on the screen.The experimenter notes the recognized verbs. The recognition of a verb in the TBF list or a distractor is considered like an error. | Day 1 |
| Reaction time (ms) on the recognition of TBR and TBF |
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Inclusion Criteria for patients:
Inclusion Criteria for volunteers:
Exclusion Criteria for patients and volunteers :
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| Name | Affiliation | Role |
|---|---|---|
| Anne GROSSELIN, MD | CHU de Saint-Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de SAINT-ETIENNE | Saint-Etienne | 42000 | France |
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Memorization of the verbs by imagining the action
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| Healthy volonteers group 3 | Active Comparator | Memorization of the action verbs by means of another word |
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| Healthy volonteers group 4 | Active Comparator | Simple memorization of the verbs |
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| Memorization of the verbs by imagining the action | Other | The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb. |
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| Memorization of the action verbs by means of another word | Other | The participant reads aloud the verbs that appear on the screen. Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one. The word is written near the action verb. |
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| Simple memorization of the verbs | Other | The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition). |
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The response times of participants are recorded in ms. |
| Day 1 |
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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