Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) will be enrolled. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QoR-40) questionnaire before their surgery and at 24 and 48 hours post op. They will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (PACU).

Inclusion Criteria:

1. The inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer
2. Adults above 20 years of age and providing informed consent.
3. American Society of Anesthesiologists (ASA) Physical class II, & III patients

Exclusion Criteria:

1. severe functional liver or kidney disease
2. history of chronic pain requiring opioid treatment
3. arrhythmia or received treatment with antiarrythmic drug .
4. severe bradycardia (HR < 45 bpm) and AV block
5. pathologic esophageal lesion (esophageal stricture or varix )
6. pregnancy
7. psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire
8. History of alcohol or drug abuse