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| ID | Type | Description | Link |
|---|---|---|---|
| 2015-A00789-40 | Other Identifier | ANSM |
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Cataract is the clouding of the lens of the eye, which initially prevents clear vision and eventually progresses to blindness if left untreated. Cataract remains the leading cause of blindness and an important cause of visual impairment across the globe. Cataract surgery by ultrasonic phacoemulsification is the most common surgery practiced in France (600 000/year)
Two sub-categories of phacoemulsification coexist :
Endocapsulars techniques represented by Divide-and-Conquer and Phaco-Chop ; and Supracapsular techniques mainly represented by Subluxation (similar to Tilt-and-Tumble) The corneal endothelium plays an important role in maintaining the dehydrated state and the transparency of the cornea. Some degree of endothelial cell loss invariably occurs in all types of cataract surgery but the amount of endothelial cell loss may varies with the type of surgical technique The aim of the study is to evaluate the density of the central corneal endothelial cells before and after cataract surgery comparing two phacoemulsification techniques (Divide-and-Conquer vs Subluxation)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subluxation | Experimental | Nucleus is hydrodissected until it lilts above the capsular bag, rotated to face the incision then tumbled and emulsification continues from the opposite equator outside in until complete |
|
| Divide and Conquer | Other | Cataract nucleus is fragmented into 4 pieces then aspirated by ultrasonic vibration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Subluxation | Procedure | One pole of The nucleus is hydrodissected until it lilts above the capsular bag. The tilted nucleus is rotated to face the incision and remaining half nucleus is then tumbled and emulsification continues from the opposite equator outside in until complete |
| Measure | Description | Time Frame |
|---|---|---|
| Main Outcome Measures: postoperative Endothelial cell loss of the central corneal | 12 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Marc PERONE, MD | CHR Metz-Thionville | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chr Metz Thionville | Metz | 57085 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34732666 | Result | Perone JM, Ghetemme C, Zevering Y, Zaidi M, Ouamara N, Goetz C, Lhuillier L. Corneal Endothelial Cell Loss After Endocapsular and Supracapsular Phacoemulsification: The PERCEPOLIS Randomized Clinical Trial. Cornea. 2022 Jun 1;41(6):714-721. doi: 10.1097/ICO.0000000000002822. Epub 2021 Nov 2. | |
| 41417772 | Derived |
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| ID | Term |
|---|---|
| D002386 | Cataract |
| ID | Term |
|---|---|
| D007905 | Lens Diseases |
| D005128 | Eye Diseases |
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| Divide and Conquer | Procedure | Cataract nucleus is fragmented into 4 pieces then aspirated by ultrasonic vibration |
|
| Leterrier J, Mastrangelo L, Goetz C, Zevering Y, Perone JM. Preoperative and perioperative factors that predict endothelial cell loss 1 year after uncomplicated Descemet membrane endothelial keratoplasty. PLoS One. 2025 Dec 19;20(12):e0339346. doi: 10.1371/journal.pone.0339346. eCollection 2025. |