Evaluation of Memantine Versus Placebo on Ischemic Stroke Outcome

The researchers aim to investigate the effect of memantine on stroke outcome in a randomized double-blind placebo-controlled clinical trial.

Inclusion Criteria:

• Presentation at first 24hrs of disease onset
• Confirmation of ischemic stroke in MCA territory by imaging.
• Accepted consent form

Exclusion Criteria:

• Allergy history to memantine
• Stage 4 -5 renal failure base on Acute Kidney Injury Network criteria
• Moderate to severe hepatic failure (Child-Pugh criteria, grade B and C)
• History of epilepsy
• History of dementia
• History of memantine use in recent 6 months
• Pregnancy or breastfeeding
• Severe drug adverse effects