The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia

The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia：A Randomized, Double Blind Controlled Trial

Evaluate safety and efficacy of dexmedetomidine in minimally invasive spine surgery under local anesthesia sedation.Explore the appropriate concentration of dexmedetomidine, whether or not can reduce the amount of local anesthetics.

Inclusion Criteria:

• Sign the informed consent；
• American Society of Anesthesiologists (ASA)classification:class I~II;Elective minimally invasive spine surgery；
• Age ≥18 years old, weighing 45 ~ 80 Kg, height 151 ~ 185 cm;
• hypertension within Ⅱ grade, or controlled with drugs within Ⅱ level；
• Diabetes fasting in 8.3mol/L or less

Exclusion Criteria:

• DEX allergy;
• Change anesthesia preoperative or intraoperative ;
• metabolic disorders, anemia has not been corrected;
• recent patients receiving sedatives and antidepressants;
• degenerative diseases of the central nervous elderly persons;
• serious central nervous system diseases (acute stroke, uncontrolled epilepsy, severe dementia);
• hypovolemia; 8) unstable angina or acute myocardial infarction;
• left ventricular ejection fraction less than 30%, heart rate lower than 45bpm;
• II-III degree heart block;
• acute hepatitis or severe liver disease (liver function C level);
• patients with renal insufficiency randomly assigned to receive treatment, but If patients need dialysis test is excluded or interruption ;