ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

A prospective pilot study to evaluate the recanalization and safety of mechanical thrombectomy through a cerebral angiogram in patients with stroke symptoms last seen normal between 8 - 24 hours.

Ischemic stroke patients who are 8-24 hrs from symptom onset without prior mechanical or IV thrombolytic treatment and are screen with CT or MR perfusion imaging showing penumbra and infarction not > 1/3rd the territory.

Inclusion Criteria:

• Over 18 years last seen normal between 8 - 24 hours, without prior history of intravenous plasminogen activator (IV t-PA ) or
• mechanical thrombectomy Vessels - intracranial vertebral artery, basilar artery, intracranial ICA, ICA terminus bifurcation, MCA M1/M2, or
• ACA NIHSS ≥ 7 MRI DWI/PWI or
• CTA/P, which demonstrates an area of mismatch ≥ 2/3 rd
• Signed informed consent

Exclusion Criteria:

• creat >= 2
• NIHSS < 7
• Baseline mRS >= 2
• infarct > 1/3rd MCA territory
• competing trials
• prior IV or IA treatment