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Obesity is associated with many undesirable health effects and disease, and middle age is associated with increased risk for disease. Unfortunately, while others have looked at the effects of obesity, gender, and middle age, the combined effects of obesity and middle age on men's ability to do work in hot industrial environments have not been satisfactorily investigated.
This small study evaluates the heat tolerance of lean and obese middle aged men both while exercising and resting and the ways in which each compensate for and dissipate increasing environmental heat and heat generated by the body while exercising.
As obesity is a worldwide public health crisis and as populations in many industrialized nations age, it is important to understand the combined effects of obesity and middle age for men on their ability to safely work in hot environments. Such information will permit establishing and revising of safe work standards and inform public health outreach to the target population, itself.
The present study was initially approved by and conducted at The Pennsylvania State University in 1972 for the senior author's (Rodger J McCormick) D.Ed. thesis in Biological Sciences; funding support was provided by the US National Institute of Arthritis, Metabolism, and Digestive Diseases Grant AM-08311 and National Institutes of Health Grant 01748. Data re-analysis and representation of that study was first approved in 2011 by and conducted at the FSRG deGruyter-McKusick Institute of Health Sciences for partial fulfillment of an MS in Clinical and Applied Physiology being pursued by the junior author (Mikaela I Poling). No funding was received for this use of existing data.
Importance of Present Study:
Several heat tolerance studies, including Kenny, Gagnon, Dorman, Hardcastle, and Joy (2010), have indicated that middle-age men can perform hard work in hot environments nearly as well as younger men. Dufour and Candas (2007), in comparing passive heat responses and sudomotor function in young, middle aged, and older men, found only local, not global, decreases in sweat gland output in the two older groups, suggesting at least some significant preservation of sudomotor function. Since most studies employed subjects with lean normal body types, their results in terms of physiological reactions to heat stress may not be applicable to obese middle aged men. Other studies have demonstrated degraded heat stress exercise capacity in obese persons.
Within high heat stress areas such as in the steel, fiberglass, aluminium, mining, professional sports, and defense industries, lean and obese middle aged men can readily be observed performing the same work task in the same hot environment. Little attention has been given to differences between the lean and obese middle aged men in their physiological responses to the combination of internal heat production from the work task performed and the heat load imposed from the external environment.
In the present study, occupational heat stress endurance differences between lean and obese middle aged men and effect of obesity are investigated under laboratory simulated conditions to test the following hypotheses: (1) with greater baseline cardiovascular demands, it is expected that obese middle aged men will have reduced environmental heat tolerance and will gain and store more total heat; (2) poorer environmental heat tolerance of obese middle aged men will be greatly magnified by work (producing added metabolic heat); (3) lean middle aged men will thermoregulate well; (4) lean middle aged men will show few, if any, major signs of inability to compensate for added cardiovascular demands; (5) obese middle aged men will be functioning at a higher percentage of their maximal ventilation of expired oxygen; and (6) obese middle aged men will have poorer pulmonary fitness, as measured by maximal ventilation of expired oxygen, than lean middle aged men.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lean | Men aged 35-55 years, having <20% body fat |
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| Obese | Men aged 35-55 years, having >29% body fat |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiopulmonary Exercise Stress Test | Procedure | Test preceded by warm-up treadmill walking 5 min at 4.8 km/h, 5% grade with a 1 min sitting rest period. Test, then, begins at 4.8 km/h, 2.5% grade with incremental grade increases every 2 min until exhaustion. Ambient environment is maintained at neutral, with effective temperature of 19-21° C. Heart, lungs, temperature, and sweating is monitored during testing. |
| Measure | Description | Time Frame |
|---|---|---|
| Core (Rectal) Temperature Change with Exercise Level and Increased Heat Load | Failure to maintain rectal temperature within 0.15° C of subject baseline for interval from end of exercise Bout 2 to Bout 3. | Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min |
| Oxygen Consumption Change with Exercise Level and Increased Heat Load | Oxygen consumption, measured by ventilation of expired oxygen, is used as a measure of physiological strain imposed by metabolic needs during exercise and exaggerated by obesity. | Evaluated near the end of Exercise Bout 1 (2 min) and 3 (2 min) |
| Heart rate Change with Exercise Level and Increased Heat Load | Increased heart rate, measured electrocardiographically, is used as an index of cardiovascular strain imposed by needs during exercise and exaggerated by obesity. | Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min |
| Difference in Routine and Maximal Ventilation of Expired Oxygen at Neutral Ambient Temperature | Warm-up approximates steady, normal work, while the progressive portion of the text places maximal metabolic burden on the subject in order to measure upper limit of heart and lung function | Cardiopulmonary Stress Test, during the last 1 min of warm-up and at end of progressive portion as volitional exhaustion approached |
| Measure | Description | Time Frame |
|---|---|---|
| Perceived Exertion Change with Exercise Level and Increased Heat Load | Increased perceived exertion is used as an index of fatigue, an indirect indicator of physiological strain. | Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min |
| Non-Invasive Arterial Blood Pressure Change with Exercise Level and Increased Heat Load |
| Measure | Description | Time Frame |
|---|---|---|
| Body Composition | Body composition, measured by calliper, together with direct indices of physiological strain, is used to determined metabolic and heat storage burden | Evaluated before exercise (20 min) |
| Age at Death or Current Age |
Inclusion Criteria:
Exclusion Criteria:
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Lean and obese middle aged men unaccustomed to working in hot industrial conditions
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| Name | Affiliation | Role |
|---|---|---|
| Rodger J McCormick, DEd | Freeman-Sheldon Research Group, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Freeman-Sheldon Research Group, Inc. Headquarters | Buckhannon | West Virginia | 26201 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 1176412 | Background | Haymes EM, McCormick RJ, Buskirk ER. Heat tolerance of exercising lean and obese prepubertal boys. J Appl Physiol. 1975 Sep;39(3):457-61. doi: 10.1152/jappl.1975.39.3.457. | |
| 19885672 | Background | Kenny GP, Gagnon D, Dorman LE, Hardcastle SG, Jay O. Heat balance and cumulative heat storage during exercise performed in the heat in physically active younger and middle-aged men. Eur J Appl Physiol. 2010 May;109(1):81-92. doi: 10.1007/s00421-009-1266-4. Epub 2009 Nov 3. |
| Label | URL |
|---|---|
| Freeman-Sheldon Research Group, Inc. (Sponsor's general website) | View source |
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| Climatic-Controlled Cardiopulmonary Exercise Stress Test | Procedure | Test includes 30 min walking bouts on the treadmill, with two 5 min sitting rest periods between bouts (Rest I and Rest II) and 15 min sitting recovery period (Rest III), in effective temperatures of 21.1 (baseline), 26.7, 29.4, 32.2, and 35.0° C. Heart, lungs, temperature, and sweating is monitored during testing. |
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| Body Composition Evaluation | Procedure | Multiple methods are used to accurately estimate percentage of body mass (weight) composed of fat, muscle, bone, and other connective tissues. Four different methods, including caliper and hydrostatic (underwater weighing) are used in this study to ensure an accurate estimation. |
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| Pre-Exercise Risk Assessment | Procedure | Includes non-invasive measurements of body functioning, a physical examination by a physician, and blood and urine testing to select subjects who can exercise with relative safety. |
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Increased non-invasive arterial blood pressure rate is used as an index of cardiovascular strain imposed by needs during exercise, is an important indicator of possible onset of shock, and exaggerated by obesity. |
| Evaluated at rest before exercise (20-25 min) and at Rest I (5 min), II (5 min), and III (15 min) |
| Heart Rhythm Change with Exercise Level and Increased Heat Load | Heart rhythms, monitored by electrocardiograph, are used as an index of cardiovascular strain imposed by needs during exercise and could be exaggerated by obesity. | Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min |
| Metabolic Rate Change with Exercise Level and Increased Heat Load | Rate of energy usage of the body calculated from ventilation of expired oxygen values | Evaluated near the end of Exercise Bout 1 (2 min) and Bout 3 (2 min). |
| Heat Load Change with Exercise Level and Increased Environmental Temperature | Calculated metabolic and environmental heat gain minus heat loss | During Rest I (5 min), II (5 min), and III (15 min) |
Total years alive, not survival after study participation
| up to 526 months |
| 17242944 | Background | Dufour A, Candas V. Ageing and thermal responses during passive heat exposure: sweating and sensory aspects. Eur J Appl Physiol. 2007 May;100(1):19-26. doi: 10.1007/s00421-007-0396-9. Epub 2007 Jan 23. |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D003075 | Coitus |
| D018761 | Multiple Endocrine Neoplasia Type 1 |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012725 | Sexual Behavior |
| D001519 | Behavior |
| D009377 | Multiple Endocrine Neoplasia |
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009378 | Neoplasms, Multiple Primary |
| D009386 | Neoplastic Syndromes, Hereditary |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
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