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Breast cancer is the most commonly diagnosed cancer in women and its definite diagnose is still challenge for radiologist. This study is going to evaluate multi-b value diffusion weighted imaging in discrimination of breast benign and malignant lesions and explore the diagnostic effect of the combination of multi-parameter. At the same time, pathological specimens of patients will be collected. The relationship between magnetic resonance(MR) parameters and pathology biomarkers will be evaluated. Hope multi-b value diffusion weighted imaging can improve diagnosis for breast lesion and provide the basis for clinical treatment. The fundamental of pathology on MR signal change will be further expounded.
Breast cancer is the most commonly diagnosed cancer in women and its definite diagnose is still challenge for radiologist. This study is going to evaluate multi-b values diffusion weighted imaging in discrimination of breast benign and malignant lesions and explore the diagnostic effect of the combination of multi-parameters. At the same time, pathological specimens of patients will be collected. The relationship between MR parameters and pathology biomarkers will be evaluated. By pre-contrast and post-contrast multi-b values diffusion weighted imaging series, patient's Apparent diffusion coefficient(ADC),tissue diffusivity (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), distributed diffusion coefficient(DDC) and alpha will be evaluated. Parameters of benign , malignant breast lesions and ipsilateral or contralateral normal breast parenchyma as a control group will be measured. Receiver operating characteristic (ROC) curve analysis is used to test the ability of different parameters in differentiating malignant from begin lesions. After Surgical operation, specimen of lesion will be collected(Not every patient's specimen will be collected. The investigators should be approved by patient themselves). The biomarkers of specimen will be detected by pathological and molecular-biological methods.Then analyze the relation between parameters of the MR imaging and pathological/molecular-biological biomarkers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| malignant group | The lesion which is malignant tumors in breast |
| |
| begin group | The lesion which is begin lesion in breast |
| |
| The control group | Patient's ipsilateral or contralateral normal breast parenchyma were collected as a control group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breast magnetic resonance scanning | Other | Just a muti-b value series in breast MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| The values of Apparent diffusion coefficient (ADC, mm^2/s), tissue diffusivity (D, mm^2/s), pseudo-diffusion coefficient (D*, mm^ 2/s) measured from the DWI image | Parameters of multiple b-value and conventional DWI: ADC (mm^2/s), D (mm^2/s), D* (mm^2/s), distributed diffusion coefficient (DDC, mm^2/s). | From first week to 92 week |
| The positive rates of molecular markers from the immunohistochemistry sections | Immunohistochemistry index (immunopositive rate, calculated with the numbers of positively labeled cells [2 fold increase vs the background] divided by the number of total cells) for estrogen receptor (ER), progesterone receptor(PR), Ki-67 (KI-67), Her 2 and Aquaporins. | From first week to 92 week |
| The density measurement of microvessel density (MVD) and microlymphatic density (MLD) | MVD: the number of microvessels divided by the observing area; MLD: the number of lymphocytes divided by the observing area. | From first week to 92 week |
| Measure | Description | Time Frame |
|---|---|---|
| Value of intraclass correlation coefficient (ICC) within inter-observe and intra-observe | The intraclass correlation coefficient(ICC) of inter-observe and intra-observe. | From 92 week to 120 week. |
| The true-positive and true-negative rates for each parameter |
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Inclusion Criteria:
Exclusion Criteria:
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Women with brest lesions.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bao Ying Chen, M . D . | Contact | 18629527901 | chenby128@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Bao Ying Chen, M . D . | Radiology department of Tang-Du hosipital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tang-Du Hospital | Recruiting | Xi’an | Shanxi | China |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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After Surgical operation, specimen of lesion will be collected(Not every patient's specimen will be collected. We should be approved by patient themselves). For analyze the relation with biomarker from the MR imaging and pathological/molecular-biological biomarkers.
The true-positive, false-positve,true-negative and false negative rates for each paramter are first calculated. Then the diagonistic sensitivity and specificity of each parameter are decided. |
| From 92 week to 120 week. |
| The values of R and P for Pearson Correlation analyses between DWI parameters and molecular/morphological markers | Correlation coefficient of each MR and pathological/molecular-biological biomarkers. | From 120 week to 130 week. |
| D017437 |
| Skin and Connective Tissue Diseases |