As it is difficult to recruit any more subjects, the investigators decided to terminate the study.

Drug-coated balloon technology (DCB) has recently attracted considerable interest as a promising alternative treatment option, particularly in the setting of in-stent restenosis (ISR). Optical coherence tomographic finding of restenosis lesions in drug-eluting stents (DESs) after Balloon Angioplasty with Two Different Paclitaxel-Coated Balloons will be compared between two paclitaxel-coated balloon devices; Pantera Lux™ and SeQuent® Please.

Inclusion Criteria:

• Patients ≥ 19 years old
• Patients eligible for percutaneous coronary intervention
• Single or more lesion(s) of restenosis requiring angioplasty in drug-eluting stent
• Reference vessel diameter of target lesion ≥2.5 mm

Exclusion Criteria:

• Cardiogenic shock
• Bifurcation lesion or totally occluded lesion
• Unprotected left main trunk lesion
• Allergies or hypersensitivities to antiplatelet, anticoagulation therapy, contrast media, or paclitaxel
• Heavy calcified (definite calcified lesions on angiogram) or extremely tortuous lesions
• Pregnant women or women with potential childbearing
• Inability to follow the patient over the period of 1 year after enrollment, as assessed by the investigator
• Inability to understand or read the informed content