Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee | NCT02528188 | Trialant

Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee | NCT02528188 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

A diagnosis of osteoarthritis of the index hip or knee based on American College of Rheumatology criteria with Kellgren Lawrence X ray Grade of 2 as diagnosed by the Central Reader

Currently receiving a stable dose regimen of oral NSAID (naproxen, celecoxib, diclofenac, aceclofenac, loxoprofen, ibuprofen, meloxicam, nabumetone, sulindac or ketoprofen) as described in the protocol along with a history of insufficient pain relief from, inability to tolerate or contraindication to taking acetaminophen and, tramadol or opioid treatments. Subjects must also maintain a stabilized, protocol specified NSAID dose regimen for at least the final 2 or 3 weeks of the Screening period

WOMAC Pain subscale score of at least 5 in the index knee or hip at Screening

Be willing to discontinue all non study pain medications for osteoarthritis and not use prohibited pain medications throughout the duration of the study

Female subjects of childbearing potential must agree to comply with protocol specified contraceptive requirements

Exclusion Criteria:

Subjects exceeding protocol defined BMI or body weight limits

History of other diseases specified in the protocol (eg, inflammatory joint diseases, crystalline diseases such as gout or pseudogout) that may involve the index joint and that could interfere with efficacy assessments

Radiographic evidence of protocol specified bone or joint conditions in any screening radiograph as determined by the central radiology reviewer

A history of osteonecrosis or osteoporotic fracture

History of significant trauma or surgery to a knee, hip or shoulder within the previous year

Planned surgical procedure during the duration of the study

Presence of conditions (eg, fibromyaliga, radiculopathy) associated with moderate to severe pain that may confound assessments or self evaluation of osteoarthritis pain

Signs or symptoms of carpal tunnel syndrome in the year prior to Screening

Considered unfit for surgery based upon American Society of Anesthesiologists physical classification system for surgery grading, or subjects who would not be willing to undergo joint replacement surgery if required

Contraindications to magnetic resonance imaging

History of intolerance or hypersensitivity to the oral NSAID (naproxen, celecoxib or diclofenac) the subject could be randomized to receive or any of its excipients or existence of a medical condition or use of concomitant medication for which the use of this NSAID is contraindicated

History of intolerance or hypersensitivity to acetaminophen or any of its excipients or existence of a medical condition or use of concomitant medication for which the use of acetaminophen is contraindicated

Use of prohibited medications without the appropriate washout period prior to Screening or Initial Pain Assessment Period

History of cancer within 5 years of Screening, except for cutaneous basal cell or squamous cell cancer resolved by excision

Subjects with signs and symptoms of clinically significant cardiac disease as described in the protocol

Diagnosis of a transient ischemic attack in the 6 months prior to Screening, diagnosis of stroke with residual deficits that would preclude completion of required study activities

History, diagnosis, or signs and symptoms of clinically significant neurological disease such as but not limited to peripheral or autonomic neuropathy

History, diagnosis, signs or symptoms of any clinically significant psychiatric disorder

History of known alcohol, analgesic or drug abuse within 2 years of Screening

Previous exposure to exogenous NGF or to an anti-NGF antibody

History of allergic or anaphylactic reaction to a therapeutic or diagnostic monoclonal antibody or IgG fusion protein

Poorly controlled hypertension as defined in the protocol or taking an antihypertensive that has not been stable for at least 1 month prior to Screening

Evidence of protocol defined orthostatic hypotension at Screening

Disqualifying score on the Survey of Autonomic Symptoms questionnaire at Screening

Screening AST, ALT, serum creatinine or HbA1c values that exceed protocol defined limits

Presence of drugs of abuse in screening urine toxicology panel

Positive hepatitis B, hepatitis C or HIV test results indicative of current infection

Participation in other investigational drug studies within protocol defined time limits

Pregnant, breastfeeding or female subjects of childbearing potential who are unwilling or unable to follow protocol required contraceptive requirements

Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that in the judgment of the investigator, would make the subject inappropriate for entry into this study

Central Alabama Research

Birmingham, Alabama 35209, United States

Achieve Clinical Research, LLC

Birmingham, Alabama 35216, United States

Alabama Clinical Therapeutics, LLC

Birmingham, Alabama 35235, United States

Alabama Orthopaedic Surgeons

Birmingham, Alabama 35235, United States

Rheumatology Associates of North Alabama, PC

Huntsville, Alabama 35801, United States

Coastal Clinical Research, Inc.

Mobile, Alabama 36608, United States

Ferguson Family Medicine

Mesa, Arizona 85215, United States

Arizona Arthritis & Rheumatology Associates, P.C.

Phoenix, Arizona 85032, United States

Arizona Research Center

Phoenix, Arizona 85053, United States

Valley Pain Consultants

Scottsdale, Arizona 85254, United States

Clinical Research Consortium

Tempe, Arizona 85283, United States

Noble Clinical Research, LLC

Tucson, Arizona 85704, United States

Quality of Life Medical & Research Centers, LLC

Tucson, Arizona 85712, United States

Tucson Orthopaedic Institute - Research Center

Tucson, Arizona 85712, United States

CHI St. Vincent Medical Group Hot Springs

Hot Springs, Arkansas 71913, United States

Chrystal Johnson

Little Rock, Arkansas 72205, United States

KLR Business Group, Inc., dba Arkansas Clinical Research

Little Rock, Arkansas 72205, United States

Larry Watkins, MD

Little Rock, Arkansas 72205, United States

Lynn Institute of the Ozarks

Little Rock, Arkansas 72205, United States

Orange County Research Institute

Anaheim, California 92801, United States

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Anaheim, California 92805, United States

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Bellflower, California 90706, United States

Osteoporosis Medical Center

Beverly Hills, California 90211, United States

Hope Clinical Research

Canoga Park, California 91303, United States

Med Center

Carmichael, California 95608, United States

Core Healthcare Group

Cerritos, California 90703, United States

Pleitez Medical Clinic

Covina, California 91723, United States

Triwest Research Associates, LLC

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Gold River, California 95670, United States

HealthCare Partners Clinical Research, LLC.

Huntington Beach, California 92646, United States

Marvel Clinical Research LLC

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BioSolutions Clinical Research Center

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InterMed Medical Group

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Advances in Medicine

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Probe Clinical Research Corporation

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University of California, Davis Health System

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University of California, Davis Medical Center

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Clinical Trials Research

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Northern California Research

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Center for Clinical Trials of Sacramento, Inc.

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Artemis Institute for Clinical Research

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Artemis Institute for Clinical Research

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Syrentis Clinical Research

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Westlake Medical Research

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Bayview Research Group

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Lewes, Delaware 19958, United States

Javed Rheumatology Associates, Inc.

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JEM Research Institute

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RASF-Clinical Research, Inc

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Boynton Beach, Florida 33472, United States

Meridien Research

Brooksville, Florida 34601, United States

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Clearwater, Florida 33756, United States

Tampa Bay Medical Research, Inc

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Midland Florida Clinical Research Center, LLC

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S&W Clinical Research

Fort Lauderdale, Florida 33306, United States

Centre for Rheumatology, Immunology and Arthritis

Fort Lauderdale, Florida 33309, United States

Clinical Physiology Associates

Fort Myers, Florida 33912, United States

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Fort Myers, Florida 33912, United States

SIMEDHealth, LLC

Gainesville, Florida 32607, United States

South Florida Clinical Trials

Hialeah, Florida 33016, United States

Pines Clinical Research Inc.

Hollywood, Florida 33024, United States

Jacksonville Center for Clinical Research

Jacksonville, Florida 32216, United States

Care Partners Clinical Research

Jacksonville, Florida 32218, United States

Clinical Neuroscience Solutions, Inc.

Jacksonville, Florida 32256, United States

Columbus Clinical Services LLC

Miami, Florida 33125, United States

Pharmax Research Clinic, Inc.

Miami, Florida 33126, United States

Clintex Research Group

Miami, Florida 33135, United States

Center for Arthritis and Rheumatic Diseases

Miami, Florida 33173, United States

Larkin Imaging Center

Miami, Florida 33173, United States

New Horizon Research Center

Miami, Florida 33175, United States

International Research Associates, LLC

Miami, Florida 33183, United States

M&M Medical Center, Inc.

Miami, Florida 33185, United States

Quality Research & Medical Center LLC

Miami, Florida 33186, United States

Renstar Medical Research

Ocala, Florida 34470, United States

American Family Medical

Ocala, Florida 34471, United States

Sensible Healthcare, LLC.

Ocoee, Florida 34761, United States

Journey Research, Inc.

Oldsmar, Florida 34677, United States

Sunshine Research Center

Opa-locka, Florida 33054, United States

Compass Research, LLC

Orlando, Florida 32806, United States

Rheumatology Associates of Central Florida, P.A.

Orlando, Florida 32806, United States

Omega Research Consultants, LLC

Orlando, Florida 32810, United States

Oviedo Medical Research, LLC

Oviedo, Florida 32765, United States

Pensacola Research Consultants, Inc., d.b.a. Avanza Medical Research Center

Pensacola, Florida 32503, United States

Sacred Heart Orthopedics

Pensacola, Florida 32503, United States

Orthopaedic Center of South Florida

Plantation, Florida 33324, United States

St. Johns Center for Clinical Research

Ponte Vedra, Florida 32081, United States

Progressive Medical Research

Port Orange, Florida 32127, United States

Accord Clinical Research, LLC

Port Orange, Florida 32129, United States

Gulfcoast Research Institute, LLC

Sarasota, Florida 34232, United States

Kennedy White Orthopaedic Center

Sarasota, Florida 34232, United States

Meridien Research

St. Petersburg, Florida 33709, United States

Precision Clinical Research, LLC.

Sunrise, Florida 33351, United States

Phoenix Clinical Research, LLC.

Tamarac, Florida 33321, United States

Clinical Research of West Florida, Inc.

Tampa, Florida 33603, United States

Stedman Clinical Trials

Tampa, Florida 33613, United States

BayCare Medical Group, Inc

Tampa, Florida 33614, United States

Compass Research North LLC

The Villages, Florida 32162, United States

Palm Beach Research Center

West Palm Beach, Florida 33409, United States

Atlanta Center for Medical Research

Atlanta, Georgia 30331, United States

Perimeter Institute for Clinical Research, Inc. DBA:/PICR Clinic

Atlanta, Georgia 30338, United States

Masters of Clinical Research, Inc.

Augusta, Georgia 30909, United States

River Birch Research Alliance, LLC

Blue Ridge, Georgia 30513, United States

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Gainesville, Georgia 30501, United States

Center for Advanced Research & Education

Gainesville, Georgia 30501, United States

Drug Studies America

Marietta, Georgia 30060, United States

Better Health Clinical Research, Inc.

Newnan, Georgia 30265, United States

Atlanta Orthopaedic Institute, LLC

Stockbridge, Georgia 30281, United States

Herman Clinical Research, LLC

Suwanee, Georgia 30024, United States

North Georgia Clinical Research

Woodstock, Georgia 30189, United States

North Georgia Internal Medicine

Woodstock, Georgia 30189, United States

East-West Medical Research Institute

Honolulu, Hawaii 96814, United States

Idaho Sports Medicine Institute

Boise, Idaho 83706, United States

Injury Care Research, LLC

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Institute Of Arthritis Research

Idaho Falls, Idaho 83404, United States

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Meridian, Idaho 83642, United States

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Chicago, Illinois 60607, United States

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Chicago, Illinois 60611, United States

Rush University Medical Center

Chicago, Illinois 60612, United States

Great Lakes Clinical Trials

Chicago, Illinois 60640, United States

Affinity Clinical Research Institute

Oak Lawn, Illinois 60453, United States

Southwest Center for Healthy Joints, S.C.

Oak Lawn, Illinois 60453, United States

Methodist Research Administration Office

Peoria, Illinois 61602, United States

UnityPoint Clinic Rheumatology

Peoria, Illinois 61602, United States

Methodist Medical Center of Illinois

Peoria, Illinois 61636, United States

OrthoIllinois

Rockford, Illinois 61114, United States

Quest Diagnostics

Rockford, Illinois 61114, United States

MediSphere Medical Research Center, LLC

Evansville, Indiana 47714, United States

Buynak Clinical Research, P.C.

Valparaiso, Indiana 46383, United States

Mid-America Physiatrists, P.A.

Overland Park, Kansas 66210, United States

Phoenix Medical Research, Inc.

Prairie Village, Kansas 66208, United States

Professional Research Network of Kansas, LLC

Wichita, Kansas 67205-1138, United States

Heartland Research Associates, LLC

Wichita, Kansas 67207, United States

Otrimed Corporation

Edgewood, Kentucky 41017, United States

Central Kentucky Research Associates, Inc.

Lexington, Kentucky 40509, United States

Baton Rouge General Medical Center-Internal Medicine Clinic

Baton Rouge, Louisiana 70806, United States

Baton Rouge General Medical Center-Midcity

Baton Rouge, Louisiana 70806, United States

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Baton Rouge, Louisiana 70809, United States

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Baton Rouge, Louisiana 70809, United States

Centex Studies, Inc.

Lake Charles, Louisiana 70601, United States

Klein & Associates, M.D., P.A.

Cumberland, Maryland 21502, United States

Arthritis Treatment Center

Frederick, Maryland 21702, United States

Klein & Associates, M.D., P.A.

Hagerstown, Maryland 21740, United States

The Center for Rheumatology and Bone Research

Wheaton, Maryland 20902, United States

Beacon Clinical Research, LLC

Quincy, Massachusetts 02169, United States

MedVadis Research Corporation

Watertown, Massachusetts 02472, United States

Great Lakes Research Group, Incorporated

Bay City, Michigan 48706, United States

Onyx Clinical Research

Caro, Michigan 48723, United States

Orthopaedic Associates of Michigan, PC

Grand Rapids, Michigan 49525, United States

June D.O. PC

Lansing, Michigan 48910, United States

Great Lakes Research Group

Pinconning, Michigan 48650, United States

Michigan Orthopaedic Spine Surgeons

Rochester Hills, Michigan 48307, United States

Medical Research Associates Inc.

Traverse City, Michigan 49686, United States

Oakland Medical Research Center

Troy, Michigan 48085, United States

Olive Branch Family Medical Center

Olive Branch, Mississippi 38654, United States

Landmark Internal Medicine

Southaven, Mississippi 38671, United States

University of Missouri Health Care-Investigational Pharmacy

Columbia, Missouri 65212, United States

University of Missouri Health Care

Columbia, Missouri 65212, United States

University of Missouri School of Medicine- Clinical Research Center

Columbia, Missouri 65212, United States

Advance Clinical Research, Inc.

St Louis, Missouri 63109, United States

Medex Healthcare Research, Inc.

St Louis, Missouri 63117, United States

Physician Research Collaboration, LLC

Lincoln, Nebraska 68516, United States

Affiliated Clinical Research, Inc.

Las Vegas, Nevada 89106, United States

Impact Clinical Trials

Las Vegas, Nevada 89106, United States

Office of Stephen H. Miller, MD

Las Vegas, Nevada 89117, United States

Clinical Research Consortium

Las Vegas, Nevada 89119, United States

Office of Robert P. Kaplan, DO

Las Vegas, Nevada 89119, United States

Advanced Biomedical Research of America

Las Vegas, Nevada 89123, United States

G. Timothy Kelly, MD

Las Vegas, Nevada 89128, United States

ActivMed Practices & Research, Inc.

Portsmouth, New Hampshire 03801, United States

Ocean Rheumatology, PA

Toms River, New Jersey 08755, United States

Premier Research

Trenton, New Jersey 08611, United States

Arthritis, Rheumatic and Back Disease Associates, PA

Voorhees Township, New Jersey 08043, United States

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico 87102, United States

New Mexico Clinical Research & Osteoporosis Center, Inc.

Albuquerque, New Mexico 87106, United States

Lovelace Scientific Resources Inc.

Albuquerque, New Mexico 87108, United States

NYU Langone Ambulatory Care Brooklyn Heights

Brooklyn, New York 11201, United States

Drug Trials Brooklyn

Brooklyn, New York 11230, United States

SPRI Clinical Trials, LLC

Brooklyn, New York 11235, United States

Drug Trials America

Hartsdale, New York 10530, United States

NYU Langone Arena Oncology, Laura and Issac Perlmutter Cancer Center, Infusion Center

Lake Success, New York 11042, United States

NYU Langone Arena Oncology, Laura and Issac Perlmutter Cancer Center

Lake Success, New York 11042, United States

NYU Langone Rheumatology Associates Long Island

Lake Success, New York 11042, United States

Lenox Hill Radiology

New York, New York 10016, United States

Manhattan Medical Research Practice PLLC

New York, New York 10016, United States

The Medical Research Network, LLC

New York, New York 10128, United States

AAIR Research Center

Rochester, New York 14618, United States

Upstate Clinical Research Associates, LLC

Williamsville, New York 14221, United States

Northstate Clinical Research, PLLC

Lenoir, North Carolina 28645, United States

Wake Internal Medicine Consultants, Inc

Raleigh, North Carolina 27612, United States

Wake Research Associates, LLC

Raleigh, North Carolina 27612, United States

The Center for Clinical Research

Winston-Salem, North Carolina 27103, United States

Lillestol Research, LLC

Fargo, North Dakota 58103, United States

Plains Clinical Research Center, LLC

Fargo, North Dakota 58104, United States

Valley Medical Research/Valley Medical Primary Care

Centerville, Ohio 45459, United States

Hightop Medical Research Center

Cincinnati, Ohio 45224, United States

New Horizons Clinical Research

Cincinnati, Ohio 45242, United States

CTI Clinical Research Center

Cincinnati, Ohio 45255, United States

Aventiv Research Inc.

Columbus, Ohio 43213, United States

Remington-Davis, Incorporated

Columbus, Ohio 43215, United States

Optimed Research LTD

Columbus, Ohio 43235, United States

Dayton Clinical Research

Dayton, Ohio 45406, United States

PriMed Clinical Research

Dayton, Ohio 45419, United States

Kettering Medical Center

Kettering, Ohio 45429, United States

Springboro Health Center

Springboro, Ohio 45066, United States

AC Clinical Research

Tiffin, Ohio 44883, United States

Glendale Medical Center

Toledo, Ohio 43614, United States

Bone Joint & Spine Surgeons, Inc.

Toledo, Ohio 43623, United States

Health Research of Oklahoma

Oklahoma City, Oklahoma 73103, United States

Lynn Health Science Institute

Oklahoma City, Oklahoma 73112, United States

University Orthopedics Center

Altoona, Pennsylvania 16602, United States

Heritage Valley Medical Group, Inc.

Beaver, Pennsylvania 15009, United States

Brandywine Clinical Research

Downingtown, Pennsylvania 19335, United States

Altoona Center for Clinical Research

Duncansville, Pennsylvania 16635, United States

The Clinical Trial Center LLC

Jenkintown, Pennsylvania 19046, United States

Founders Research Corporation

Philadelphia, Pennsylvania 19114, United States

The Arthritis Group

Philadelphia, Pennsylvania 19152, United States

Clinical Research Center of Reading, LLC

Wyomissing, Pennsylvania 19610, United States

Main Street Physician's Care - Waterway

Little River, South Carolina 29566, United States

Main Street Physician's Care - Loris

Loris, South Carolina 29569, United States

North Myrtle Beach Family Practice

North Myrtle Beach, South Carolina 29582, United States

Clinical Research Solutions

Jackson, Tennessee 38305, United States

Physicians Quality Care

Jackson, Tennessee 38305, United States

PMG Research, Inc. d/b/a PMG Research of Knoxville

Jefferson City, Tennessee 37760, United States

PCET Research Center, LLC

Knoxville, Tennessee 37909, United States

Diagnostic Imaging PC

Memphis, Tennessee 38119, United States

ARC Clinical Research at Wilson Parke

Austin, Texas 78726, United States

Tekton Research, Inc.

Austin, Texas 78745, United States

Urgent Care MD's

Baytown, Texas 77521, United States

Texas Orthopedic Specialists, PLLC

Bedford, Texas 76021, United States

Galenos Research

Dallas, Texas 75251, United States

Abigail R. Neiman, MD, PA

Houston, Texas 77024, United States

Advances in Health

Houston, Texas 77030, United States

Mercury Clinical Research, Inc.

Houston, Texas 77036, United States

Centex Studies, Inc.

Houston, Texas 77058, United States

Memorial Pulmonology

Houston, Texas 77079, United States

BI Research Center

Houston, Texas 77084, United States

Clinical Investigations of Texas

Plano, Texas 75075, United States

ClinRX Research

Richardson, Texas 75080, United States

Quality Research, Inc.

San Antonio, Texas 78209, United States

Lee Medical Associates PA

San Antonio, Texas 78213, United States

Progressive Clinical Research, PA

San Antonio, Texas 78213, United States

Sun Research Institute

San Antonio, Texas 78215, United States

Panacea Clinical Research

San Antonio, Texas 78228, United States

Accurate Clinical Research Inc.

San Antonio, Texas 78229, United States

Diagnostics Research Group

San Antonio, Texas 78229, United States

Victorium Clinical Research

San Antonio, Texas 78230, United States

DCT-Stone Oak, LLC dba Discovery Clinical Trials

San Antonio, Texas 78258, United States

South Texas Radiology Imaging Centers

San Antonio, Texas 78258, United States

Envision Imaging

Southlake, Texas 76092, United States

Oakbend Medical Center

Sugar Land, Texas 77479, United States

ClinPoint Trials

Waxahachie, Texas 75165, United States

Mercury Clinical Research

Webester, Texas 77598, United States

Clinics of North Texas

Wichita Falls, Texas 76302, United States

Grayline Clinical Drug Trials

Wichita Falls, Texas 76309, United States

Granger Medical Clinic-Riverton

Riverton, Utah 84065, United States

Millennium Clinical Trials, LLC

Arlington, Virginia 22207, United States

Charlottesville Medical Research Center, LLC

Charlottesville, Virginia 22911, United States

Millennium Clinical Trials

Fairfax, Virginia 22031, United States

National Clinical Research-Norfolk, Inc.

Norfolk, Virginia 23502, United States

Northwest Clinical Research Center

Bellevue, Washington 98007, United States

Optimed Research, LTD

Bellingham, Washington 98225, United States

Swedish Medical Center Investigational Drug Services Pharmacy

Seattle, Washington 98104, United States

Seattle Rheumatology Associates

Seattle, Washington 98122, United States

Swedish Medical Center

Seattle, Washington 98122, United States

Genesis Research Services

Broadmeadow, New South Wales 2292, Australia

Hunter Imaging Group

Cardiff, New South Wales 2285, Australia

Optimus Clinical Research Pty Ltd

Kogarah, New South Wales 2217, Australia

Southern Radiology

Miranda, New South Wales 2228, Australia

Royal Hospital for Women

Randwick, New South Wales 2031, Australia

Castlereagh Imaging

St Leonards, New South Wales 2065, Australia

Royal North Shore Hospital

St Leonards, New South Wales 2065, Australia

Australian Clinical Research Network

Sydney, New South Wales 2035, Australia

Spectrum Medical Imaging

Sydney, New South Wales 2035, Australia

AusTrials Pty Ltd

Sherwood, Queensland 4075, Australia

CMAX Clinical Research Pty Ltd

Adelaide, South Australia 5000, Australia

Royal Adelaide Hospital Pharmacy

Adelaide, South Australia 5000, Australia

Bensons Radiology

North Adelaide, South Australia 5006, Australia

Emeritus Research

Camberwell, Victoria 3124, Australia

Capital Radiology-Malvern

Melbourne, Victoria 3144, Australia

Capital Radiology-Clayton

Melbourne, Victoria 3168, Australia

SKG Radiology Hollywood

Nedlands, Western Australia 6009, Australia

RK Will Pty Ltd

Victoria Park, Western Australia 6100, Australia

CMIP-Centro Mineiro de Pesquisa LTDA

Juiz de Fora, Minas Gerais 36010-570, Brazil

CCBR - Centro de Pesquisas e Analises Clinicas LTDA

Rio de Janeiro, Rio de Janeiro 22271-100, Brazil

CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda

São Paulo, São Paulo 04266-010, Brazil

Diagnostic Consultative Center "Sveti Georgi" EOOD

Plovdiv, 4000, Bulgaria

Medical Center "Health for all" - EOOD

Plovdiv, 4000, Bulgaria

UMHAT Kaspela - EOOD Rheumatology Clinic

Plovdiv, 4001, Bulgaria

UMHAT Kaspela - EOOD

Plovdiv, 4001, Bulgaria

"Medical Center Teodora" EOOD

Rousse, 7012, Bulgaria

Diagnostic Consultative Center 17 Sofia EOOD

Sofia, 1505, Bulgaria

UMHAT Sveti Ivan Rilski- EAD

Sofia, 1612, Bulgaria

UMHAT "Sofiamed" OOD, Block 2

Sofia, 1750, Bulgaria

"Medical Center- Dr. Hayvazov" EOOD

Sofia, 1784, Bulgaria

Centro Integral de Reumatologia Reumalab S.A.S.

Medellín, Antioquia 05001000, Colombia

Centro de Investigacion en Reumatologia y Especialidades Medicas SAS CIREEM SAS

Bogotá, Bogota DC 110221, Colombia

Medicinski centar Kuna&Peric

Zagreb, 10000, Croatia

National Hospital Organization Toyohashi Medical Center

Toyohashi, Aichi-ken 440-8510, Japan

Funabashi Municipal Medical Center

Funabashi, Chiba 273-8588, Japan

Matsudo City General Hospital

Matsudo, Chiba 270-2296, Japan

Kanbara Clinic

Kitakyushu, Fukuoka 806-0026, Japan

Hidaka Orthopedic Hospital

Kurume, Fukuoka 830-0053, Japan

Obase Hospital

Miyako-gun, Fukuoka 800-0344, Japan

Himeno Hospital

Yamegun, Fukuoka 834-0115, Japan

Ikeda Kinen Hospital

Sukagawa, Fukushima 962-0001, Japan

Zenshukai Hospital

Maebashi, Gunma 379-2115, Japan

Mazda Hospital

Aki-gun, Hiroshima 735-8585, Japan

Medical Corporation Okimoto Clinic

Kure, Hiroshima 734-0304, Japan

Medical Corporation Emu Emukai, Matterhorn Rehabilitation Hospital

Kure, Hiroshima 737-0046, Japan

Takahashi Orthopedics Clinic

Chitose, Hokkaido 066-0062, Japan

Obihiro Orthopaedic Hospital

Obihiro, Hokkaido 080-0802, Japan

Okubo Hospital

Akashi, Hyōgo 674-0051, Japan

Omuro Orthopedic Clinic

Himeji, Hyōgo 670-0976, Japan

Medical corporate corporation hoshikai Onishi medical clinic

Kako-gun, Hyōgo 675-1115, Japan

Kobe Red Cross Hospital

Kobe, Hyōgo 651-0073, Japan

Mito Saiseikai General Hospital

Mito, Ibaraki 311-4198, Japan

National Hospital Organization Kanazawa Medical Center

Kanazawa, Ishikawa-ken 920-8650, Japan

Kokan Clinic

Kawasaki, Kanagawa 210-0852, Japan

Misugikai Medical Corporation Otokoyama Hospital

Yawata, Kyoto 614-8366, Japan

Nakajo Orthopedic Clinic

Sendai, Miyagi 983-0862, Japan

Marunouchi Hospital

Matsumoto, Nagano 390-8601, Japan

Oita University Hospital

Yufu, Oita Prefecture 879-5593, Japan

Sobajima Clinic/Orthopedics

Higashiosaka, Osaka 577-0011, Japan

Rinku General Medical Center

Izumisano, Osaka 598-8577, Japan

Kishiwada Tokushukai Hospital

Kishiwada, Osaka 596-8522, Japan

Social Welfare Organization Saiseikai Imperial Gift Foundation,Inc. Osaka Saiseikai Nakatsu Hospital

Osaka, Osaka 530-0012, Japan

Osaka University Hospital

Suita, Osaka 565-0871, Japan

Shimane University Hospital

Izumo, Shimane 693-8501, Japan

Fujieda Municipal General Hospital

Fujieda, Shizuoka 426-8677, Japan

JA Shizuoka Kohseiren Enshu Hospital

Hamamatsu, Shizuoka 430-0929, Japan

Japanese Red Cross Hamamatsu Hospital

Hamamatsu, Shizuoka 434-8533, Japan

Sonodakai Joint Replacement Center Hospital

Adachi-ku, Tokyo 121-0064, Japan

Medical Plaza Edogawa

Edogawa-ku, Tokyo 133-0052, Japan

Sato Orthopaedic Clinic

Edogawa-ku, Tokyo 134-0084, Japan

Fussa Hospital

Fussa, Tokyo 197-8511, Japan

Jukoukai hospital

Koto-ku, Tokyo 136-0073, Japan

Kitasato University Kitasato Institute Hospital

Minato-ku, Tokyo 108-8642, Japan

Tamagawa Hospital

Setagaya-ku, Tokyo 158-0095, Japan

Kohno Clinical Medicine Research Institute Daisan Kitashinagawa Hospital

Shinagawa-ku, Tokyo 140-0001, Japan

Ohimachi Orthopaedic Clinic

Shinagawa-ku, Tokyo 140-0014, Japan

Japan Organization of Occupational Health and Safety Sanin Rosai Hospital

Yonago, Tottori 683-8605, Japan

National Hospital Organization Chiba Medical Center

Chiba, 260-8606, Japan

Chihaya Hospital

Fukuoka, 813-8501, Japan

Kuroda Orthopedic Hospital

Fukuoka, 814-0165, Japan

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Hiroshima, 730-8619, Japan

Hiroshima Prefectural Hospital

Hiroshima, 734-8530, Japan

Kumamoto Orthopaedic Hospital

Kumamoto, 862-0976, Japan

Nagayoshi General Hospital

Osaka, 547-0016, Japan

Iwasaki Orthopedic Surgery

Saitama, 330-0056, Japan

Saitama Municipal Hospital

Saitama, 336-8522, Japan

Saules seimos medicinos centras

Kaunas, LT-49449, Lithuania

Klaipeda University Hospital

Klaipėda, LT-92288, Lithuania

Republican Siauliai Hospital

Šiauliai, LT-76231, Lithuania

Centro Hospitalario Mac, S.A. de C.V.

Guadajara, Jalisco 45050, Mexico

Consultorio Medico del Dr. Federico Galvan Villegas

Guadalajara, Jalisco 45040, Mexico

Lakeland Clinical Trials

Rotorua, BOP 3010, New Zealand

Otago Radiology

Dunedin, Otago 9010, New Zealand

RMC Medical Research Ltd

Dunedin, Otago 9012, New Zealand

South Pacific Clinical Trials

Auckland, 0610, New Zealand

TRG Imaging Lincoln Road

Auckland, 0610, New Zealand

Auckland Bone Density Ltd

Auckland, 0612, New Zealand

North Shore Hospital, Waitemata District Health Board

Auckland, 0622, New Zealand

Star Unit, North Shore Hospital, Waitemata District Health Board

Auckland, 0622, New Zealand

The Radiology Group

Auckland, 0622, New Zealand

Southern Clinical Trials- Waitemata Ltd

Auckland, 0626, New Zealand

Auckland Bone Density

Auckland, 0632, New Zealand

Optimal Clinical Trials

Auckland, 1010, New Zealand

Auckland Radiology Parnell Branch

Auckland, 1052, New Zealand

Southern Clinical Trials Ltd

Christchurch, 8013, New Zealand

Collingwood Street Pharmacy

Nelson, 7010, New Zealand

Nelson Radiology

Nelson, 7010, New Zealand

Porter Rheumatology Ltd

Nelson, 7010, New Zealand

Bay Radiology

Tauranga, 3110, New Zealand

P3 Research Ltd

Tauranga, 3110, New Zealand

Clinical Horizons NZ Ltd

Tauranga, 3112, New Zealand

P3 Research Ltd

Wellington, 6021, New Zealand

Pacific Radiology

Wellington, 6021, New Zealand

Unidad de Investigacion en Medicina Interna y Enfermedades criticas-Hogar Clinica San Juan de Dios

Cayma, Arequipa, Peru

Centro De Investigacion Clinica Trujillo EIRL/Clinica Peruano Americana S.A.

Trujillo, La Libertad 13001, Peru

ABK REUMA S.R.L. de Medicentro Biociencias/BIO CIENCIAS PERU S.R.L.

Lima, 21, Peru

Centro de Investigación Reumatología CAA-Clinica Anglo Americana

Lima, 27, Peru

Investigaciones en Reumatologia / Centro Medico Corpac S.A.

Lima, 27, Peru

Centro de Investigaciones Medicas-Hospital Maria Auxiliadora

Lima, 29, Peru

Investigaciones Clinicas S.A.C. / Instituto de Ginecologia y Reproduccion S.A.

Lima, 33, Peru

Investigaciones Clinicas S.A.C./Instituto de Ginecologia y Reproduccion S.A.

Lima, 33, Peru

Philippine General Hospital

Manila, NCR 1000, Philippines

Manila Doctors Hospital

Manila, 1000, Philippines

Moscow Municipal Rheumatology Center

Moscow, 119049, Russia

SBHI "City Clinical Hospital No. 1 n.a N.I. Pirogov"

Moscow, 119049, Russia

SBHI "City Clinical Hospital No. 1 n.a. N.I. Pirogov"

Moscow, 119049, Russia

Federal State Budgetary Scientific Research institution of fundamental and clinical immunology

Novosibirsk, 630047, Russia

Federal State Budgetary Scientific Institution

Novosibirsk, 630117, Russia

State Budgetary Institution of Ryazan Region

Ryazan, 390026, Russia

Medical Technologies Ltd

Saint Petersburg, 191025, Russia

Limited Liability Company "Medical Center "Reavita Med SPb"

Saint Petersburg, 194354, Russia

Medinet LLC

Saint Petersburg, 194356, Russia

FSBI 'SRITO n.a. R.R. Vreden' MoH RF

Saint Petersburg, 195427, Russia

Institute for Rehabilitation

Belgrade, 11000, Serbia

Institute of Rheumatology

Belgrade, 11000, Serbia

Institute for treatment and rehabilitation "Niska Banja"

Niška Banja, 18205, Serbia

Special Hospital for Rheumatic Diseases Novi Sad

Novi Sad, 21000, Serbia

General hospital "Dr Laza K. Lazarevic" Sabac

Šabac, 15000, Serbia

Reumatologia s.r.o.

Bratislava, 820 07, Slovakia

Nestatna Reumatologicka Ambulancia, Poliklinika Karlova Ves

Bratislava, 841 04, Slovakia

MUDr. STRANAI s.r.o.

Košice, 040 11, Slovakia

Reum.hapi s.r.o.

Nové Mesto nad Váhom, 91501, Slovakia

MEDIPA s.r.o.

Piešťany, 921 01, Slovakia

Thermium s.r.o.

Piešťany, 92101, Slovakia

Daegu Catholic University Medical Center

Daegu, 42472, South Korea

Department of Radiology

Daegu, 42472, South Korea

Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University Medical Center

Daegu, 42472, South Korea

Chungnam National University Hospital

Daejeon, 35015, South Korea

Clinical Trial Center Pharmacy

Daejeon, 35015, South Korea

Department of Radiology

Daejeon, 35015, South Korea

Chonnam National University Hospital

Gwangju, 61469, South Korea

Department of Radiology

Gwangju, 61469, South Korea

Pharmacy of Clinical Trial Center

Gwangju, 61469, South Korea

Clinical Trial Pharmacy

Seoul, 02841, South Korea

Department of Radiology

Seoul, 02841, South Korea

Korea University Anam Hospital

Seoul, 02841, South Korea

Clinical Trials Center Pharmacy

Seoul, 03080, South Korea

Seoul National University Hospital

Seoul, 03080, South Korea

Clinical Trial Center Pharmacy

Seoul, 03722, South Korea

Department of Radiology

Seoul, 03722, South Korea

Yonsei University Health System, Severance Hospital

Seoul, 03722, South Korea

Clinical Research Pharmacy

Seoul, 05030, South Korea

Department of Clinical Research Pharmacy, Konkuk University Medical Center

Seoul, 05030, South Korea

Department of Radiology

Seoul, 05030, South Korea

Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center

Seoul, 05030, South Korea

Konkuk University Medical Center

Seoul, 05030, South Korea

Clinical Trial Center Pharmacy

Seoul, 06351, South Korea

Department of Orthopedic Surgery, Samsung Medical Center

Seoul, 06351, South Korea

Clinical Trial Pharmacy

Seoul, 06591, South Korea

Department of Radiology

Seoul, 06591, South Korea

The Catholic University of Korea Seoul St. Mary's Hospital

Seoul, 06591, South Korea

Clinical Research Pharmacy, SMG SNU Boramae Medical Center

Seoul, 07061, South Korea

Department of Clinical Research Pharmacy, SMG-SNU Boramae Medical Center

Seoul, 07061, South Korea

Department of Radiology

Seoul, 07061, South Korea

SMG-SNU Boramae Medical Center

Seoul, 07061, South Korea

Department of Radiology

Seoul, 07985, South Korea

Ewha Womans University Mokdong Hospital

Seoul, 07985, South Korea

Clinical Trial Pharmacy

Yangcheon-gu, Seoul, 07985, South Korea

Changhua Christian Hospital Clinical Trial Pharmacy

Changhua, 500, Taiwan

Changhua Christian Hospital

Changhua, 500, Taiwan

Chang Gung Memorial Hospital-Kaohsiung Branch Clinical Trial Pharmacy

Kaohsiung City, 83301, Taiwan

Chang Gung Memorial Hospital-Kaohsiung Branch

Kaohsiung City, 83301, Taiwan

Chung Shan Medical University Hospital Clinical Trial Pharmacy

Taichung, 402, Taiwan

Chung Shan Medical University Hospital

Taichung, 402, Taiwan

China Medical University Hospital

Taichung, 40447, Taiwan

Department of Pharmacy, China Medical University Hospital

Taichung, 40447, Taiwan

Regional Communal Institution Chernivtsi Regional Clinical Hospital

Chernivtsi, 58001, Ukraine

Communal Non-profit Institution "City Clinical Hospital No.27" of Kharkiv City Council

Kharkiv, 61002, Ukraine

Government Institution "L.T. Malaya Therapy National Institute of the NAMS of Ukraine"

Kharkiv, 61039, Ukraine

Chair of Internal Medicine #2

Kyiv, 01601, Ukraine

Oleksandrivska Clinical Hospital Of Kyiv

Kyiv, 01601, Ukraine

Kyiv City Clinical Hospital 3,Rheumatology Department

Kyiv, 02125, Ukraine

Clinic of NI "NSC"M.D.Strazhesko Institute of Cardiology" of NAMS of Ukraine,

Kyiv, 03151, Ukraine

Polyclinic of Administration of Medical Services and Rehabilitation of State Stock Holding Company

Kyiv, 04050, Ukraine

Clinic of SI "Institute of Gerontology named after D.F Chebotarov of NAMS of Ukraine"

Kyiv, 04114, Ukraine

Clinic of SI Institute of Gerontology named after D.F Chebotarov of NAMS of Ukraine

Kyiv, 04114, Ukraine

National Medical University named after O O Bogomolets,

Kyiv, 04119, Ukraine

Polyclinic Of Administration of Medical Services and Rehabilitation of SSHC Artem

Kyiv, 04119, Ukraine

Communal Non-profit Institution "City Clinical Hospital #5 of Lviv", Therapeutics Department

Lviv, 79013, Ukraine

Communal Institution "Odesa Regional Clinical Hospital"

Odesa, 65025, Ukraine

Multi-field Medical Center (University Clinic No.1) of Odesa National Medical University,

Odesa, 65026, Ukraine

Communal Institution Ternopil University Hospital

Ternopil, 46002, Ukraine

Vinnytsia Regional Clinical Hospital named after M.I. Pyrogov, Rheumatology Department,

Vinnytsia, 21018, Ukraine

Communal Non-commercial Enterprise "Vinnytsia City Clinical Hospital No 1"

Vinnytsia, 21029, Ukraine

Medical Clinical Investigational Centre of Medical Centre Health Clinic LTD

Vinnytsia, 21029, Ukraine

Scientific and Research Institute of Invalid Rehabilitation (Educational and Scientific Medical

Vinnytsia, 21029, Ukraine

Vinnytsya Medical National University named after M.I. Pyrogov, Chair of Internal Medicine #3

Vinnytsia, 21029, Ukraine

Communal Institution Zaporizhzhya Regional Clinical Hospital

Zaporizhzhya, 69600, Ukraine