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The estimation of the cardiovascular risk in the general population must take into account small renal disturbances, as the microalbuminuria. Conversely certain parameters of the cardiovascular risk influence the evolution of renal diseases, for example the arterial high blood pressure.
The measure of the activity of the autonomous nervous system, and especially the quantification of its variability, is a means to estimate the cardiovascular risk. The investigators formulate the hypothesis that the variability of the autonomous nervous system is an additional clinical element for the evaluation of the evolutionary risk of renal diseases.
The aim of this study is to compare the variability of the autonomous nervous system during the various evolutionary stages of the renal disease.
The renal disease studied will be IgA nephropathy (IgNA). IgNA is a histologically defined glomerulonephritis (rela biopsy) by the presence of deposits immunoglobulin A (IgA) in the renal mesangium (at list 1+) by immunofluorescence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IgAN with glomerular filtration rate (GFR) >90 ml/min/1.73 m2 | Experimental | Measure of ANS by holter device in IgAN patients with glomerular filtration rate (GFR) >90 ml/min/1.73 m2 |
|
| IgAN with GFR 60-89 ml/min/1.73 m2 | Experimental | Measure of ANS by holter device in IgAN patients with GFR 60-89 ml/min/1.73 m2 |
|
| IgAN with GFR 30-59 ml/min/1.73 m2 | Experimental | Measure of ANS by holter device in IgAN patients with GFR 30-59 ml/min/1.73 m2 |
|
| IgAN with GFR 15-29 ml/min/1.73 m2 | Experimental | Measure of ANS by holter device in IgAN patients with GFR 15-29 ml/min/1.73 m2 |
|
| IgAN with GFR < 15ml/min/1.73 m2 | Experimental | Measure of ANS by holter device in IgAN patients with GFR < 15ml/min/1.73 m2. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Holter | Device | measure of ANS in IgAN patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Standard deviation of all R-R intervals (SDNN) | Comparison of Standard deviation of all R-R intervals (SDNN) between GFR category of IgNA | day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Alamartine, PhD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Saint-Etienne | Saint-Etienne | 42055 | France |
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| ID | Term |
|---|---|
| D005922 | Glomerulonephritis, IGA |
| ID | Term |
|---|---|
| D005921 | Glomerulonephritis |
| D009393 | Nephritis |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| ID | Term |
|---|---|
| D015716 | Electrocardiography, Ambulatory |
| ID | Term |
|---|---|
| D004562 | Electrocardiography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
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| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D003933 | Diagnosis |
| D004568 | Electrodiagnosis |
| D018670 | Monitoring, Ambulatory |
| D008991 | Monitoring, Physiologic |