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This is a multicenter, prospective observational cohort study, in which patients with chronic airway diseases including chronic obstructive pulmonary disease(COPD), asthma, asthma-COPD overlap syndrome (ACOS) will be recruited.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No predefined subgroups |
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| Measure | Description | Time Frame |
|---|---|---|
| Death (time to death) | death from any cause, death from COPD-specific cause, death from CVD, malignancy | upto 20 years |
| Measure | Description | Time Frame |
|---|---|---|
| post-bronchodilator FEV1 change rates | upto 20 years (at least 3 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Time to 1st exacerbation (definition of exacerbation is described below) | Definition of exacerbation: Airway disease symptom aggravation requiring either (1) Use of antibiotics or steroid, or (2) visiting ER or hospitalization | upto 20 years |
| Annual rate of exacerbation (definition of exacerbation is described below) |
COPD
Inclusion Criteria:
Exclusion Criteria:
-
Asthma
Inclusion Criteria:
Exclusion Criteria:
-
ACOS
Inclusion Criteria:
Exclusion Criteria:
-
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COPD Asthma ACOS Bronchiectasis TB-destroyed lung Other chronic airway diseases
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chang-Hoon Lee, M.D. | Contact | 82-2-2072-4743 | kauri670@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Chul-Gyu Yoo, M.D. | Seoul National University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29482616 | Derived | Jo YS, Park S, Kim DK, Yoo CG, Lee CH. The cutoff point of clinical chronic obstructive pulmonary disease questionnaire for more symptomatic patients. BMC Pulm Med. 2018 Feb 27;18(1):38. doi: 10.1186/s12890-018-0601-0. | |
| 28583262 | Derived | Jo YS, Lee J, Yoon HI, Kim DK, Yoo CG, Lee CH. Different prevalence and clinical characteristics of asthma-chronic obstructive pulmonary disease overlap syndrome according to accepted criteria. Ann Allergy Asthma Immunol. 2017 Jun;118(6):696-703.e1. doi: 10.1016/j.anai.2017.04.010. |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D001249 | Asthma |
| D001987 | Bronchiectasis |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Blood (whole blood, serum, plasma, buffy coat) Urine
Definition of exacerbation: Airway disease symptom aggravation requiring either (1) Use of antibiotics or steroid, or (2) visiting ER or hospitalization |
| upto 20 years |
| Seoul National University Hospital | Recruiting | Seoul | 110-744 | South Korea |
|
| Seoul Metropolitan Government-Seoul National University Boramae Medical Center | Active, not recruiting | Seoul | 156-707 | South Korea |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001982 | Bronchial Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |