Evaluation by HR-pQCT of Bone Microarchitecture Changes in Patients With Rheumatoid Arthritis Under Anti-TNF Therapy.

Evaluation by HR-pQCT of Bone Microarchitecture Changes in Patients With Rheumatoid Arthritis Under Anti-TNF Therapy.

Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease in adults and is characterized by chronic inflammation of the joints leading to their destruction, resulting in a major loss of function.

The investigators propose a pilot study for studying changes in bone microarchitecture with High Resolution peripheral micro Computerized Tomography (HR-pQCT) in patients with RA treated with anti-TNF(Tumor Necrosis Factor), with the measurement of micro-architectural parameters in subchondral area near an inflammatory joint during the first 12 months of initiation of an anti-TNF therapy (Infliximab®, Etanercept®, Adalimumab®).

Inclusion Criteria:

• Men from 18 to 65 years old
• Women from 18 years old to menopause
• Patient with a polyarthritis rheumatoid no controlled by the usual treatment (DAS28>3)
• Patient affiliated or beneficiary of a national insurance system
• Patient with signed consent

Exclusion Criteria:

• Concomitant osseous disease (Paget's disease, osteomalacia...)
• Endocrinopathy defined on biological criteria (Cushing's disease, hyperthyroidism, hypogonadism...)
• Patients under protection of justice
• Refusal consent