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| Name | Class |
|---|---|
| Aarhus University Hospital | OTHER |
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To extend the duration of peripheral nerve blockade after major foot and ankle surgery the investigators randomize the postoperative treatment with either perineurial sciatic nerve blocks with 0.5% Bupivacaine-Epinephrine with or without Dexamethasone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group BA | Active Comparator | Bupivacaine + Adrenaline Sciatic nerve block with Bupivacaine 0.5% + Epinephrine 5 microg/ml |
|
| Group BAD | Experimental | Bupivacine + Adrenaline + Dexamethasone Sciatic nerve block with Bupivacaine 0.5% + Epinephrine 5 microg/ml PLUS Dexamethsone 8 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine | Drug | Sciatic nerve block |
|
| Measure | Description | Time Frame |
|---|---|---|
| Painfree period (time until first pain sensation in operated foot) | Patients are closely monitored in the PACU until first pain sensation in the operated foot. | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Pain in the operated foot, measured on a numeric rating scale (0-10) | Pain score at rest, with the operated foot elevated on a pillow, ranging from 0 [no pain] to 10 [worst possible pain] | Every 30 minuttes from the patient enters the PACU to the nerve block wears of |
| Sensibility score, measured with a hided tactile pinprick-sensation under the 3.rd toe on the operated foot |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesia, Aarhus University Hospital | Aarhus | Region Midt | 8000 | Denmark |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D004837 | Epinephrine |
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Epinephrine | Drug | Adjuvant to perinerual block |
|
|
| Dexamethasone | Drug | Adjuvant to perinerual block |
|
|
Sensitivy score measured on a 3 point scale 0 (no sensation) (impared sensation) 2 (full or normal sensation) compared to non-operated side |
| Every 30 minutes from the patient enters the PACU to the sensations core reach 2 |
| Total consumption of opioids during the length of stay | A cummulative calculation of equipotente doses of oral milligrams of morphin during the length of stay | 48 hours |
| quality of sleep first night measured on a 3 point scale | Quality of sleep measured on the morning after operation. 0 (good sleep, no interruptions) by pain from operated foot) 1 (sleep, but interruption without pain) 2 (sleep but interrupted by pain from operated foot) | hours |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D000588 |
| Amines |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |