Dumping Syndrome After Operation of Esophageal Atresia Type III

Frequency of Occurrence of Dumping Syndrome After Operation of Esophageal Atresia Type III

The purpose of this study is to evaluate the prevalence at 3.5 months of age of dumping syndrome in children operated at birth for oesophageal atresia type III et IV.

Consecutive patients with type III and IV oesophageal atresia that are born in 8 different centers in France and Sydney (Australia) are included in the study, if willing. As soon as they weigh more than 4.150kg and if they are still younger than 3.5 months, an Oral Glucose Tolerance Test (OGTT) is performed. Glycemia and insulinemia are monitored every 30 minutes from intake to 240 minutes. Clinical signs that are presented are noted. If early hyperglycemia or late hypoglycemia are biologically or clinically observed, ascarbose treatment is initiated.

Inclusion Criteria:

• New born less than 3.5 months or age corrected for premature new born
• Weight ≥ 4, 150 kg
• Esophageal atresia (EA) type III or IV
• EA Surgery between May 2013 and June 2016
• Stop of prokinetic treatment > 72 h before OGTT
• Information and consent of parents
• Patients with health insurance

Exclusion Criteria:

• Age > 3.5 months
• Weight < 4.150 kg
• Other types of EA
• Dumping syndrom from other origin: microgastria, dysautonomia, small intestine surgery
• Other pathology that can modify glycemia: neonatal diabete, hyperinsulinism
• Treatment that can modify gastric motility: domperidone, erythromycin, baclofen that hasn't been stopped in the 72h before OGTT
• Absence of consent
• Patient judiciary protected
• Simultaneous participation to another clinical trial
• No health insurance