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Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Latanoprost | Experimental | solution, 1 drop of 50ug/ml latanoprost, was given to study eye after washout period of 1 week between drugs |
|
| Timolol | Experimental | solution, 1 drop of 5mg/ml timolol , was given to study eye after washout period of 1 week between drugs |
|
| dorzolamide | Experimental | solution, 1 drop of 20 mg/ml dorzolamide, was given to study eye after washout period of 1 week between drugs |
|
| Other | No Intervention | no drug given and pupil measurements were performed before and at 30 and 180 min at equivalent hours as drugs measurements |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Latanoprost | Drug | 1 drop of latanoprost was given to study eye after washout period of 1 week between drugs |
|
| Measure | Description | Time Frame |
|---|---|---|
| pupillary constriction measured as the post-illimination pupillay response (PIPR) | The pupillary diameter 0 to 10 seconds after light stimulation, the diameter is measured relative to the initial dark adapted pupil diameter | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Henrik Lund-Andersen, Professor | Head of the project | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Glostrup University Hospital | Glostrup Municipality | DK-2600 | Denmark |
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| ID | Term |
|---|---|
| D000077338 | Latanoprost |
| D013999 | Timolol |
| C062765 | dorzolamide |
| ID | Term |
|---|---|
| D011461 | Prostaglandins F, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
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| Timolol | Drug | 1 drop of timolol was given to study eye after washout period of 1 week between drugs |
|
|
| Dorzolamide | Drug | 1 drop of dorzolamide was given to study eye after washout period of 1 week between drugs |
|
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D013830 | Thiadiazoles |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009025 | Morpholines |
| D010078 | Oxazines |